◀ Back to RELA
CPOX — RELA
Text-mined interactions from Literome
Chen et al., J Biol Chem 1999
:
The
cyclooxygenase-2 (COX-2) inhibitors, NS-398 and indomethacin,
attenuated LPS induced NO release, iNOS expression, and
NF-kappaB DNA-protein complex formation
Plummer et al., Oncogene 1999
(Colonic Neoplasms) :
Induction of
COX2 by inflammatory cytokines or hypoxia induced oxidative stress can be
mediated by
nuclear factor kappa B (NF-kappaB)
Lee et al., J Biol Chem 2000
:
Incubation of macrophages with PAO1 led to
NF-kappaB dependent expression of inducible nitric-oxide synthase,
COX-2 , and tumor necrosis factor-alpha, which was unaffected by inhibition of Rac1 or Cdc42 function
Nakao et al., Mol Cell Biochem 2000
:
Activation of
NFkappaB is
necessary for IL-1beta induced
cyclooxygenase-2 (COX-2) expression in human gingival fibroblasts
Hao et al., J Clin Invest 2000
(Dehydration) :
RMIC
COX2 expression was also
induced by driving
NF-kappaB activation with a constitutively active IkappaB kinase alpha (IKKalpha)
López-Urrutia et al., Biochem Biophys Res Commun 2001
(Brucellosis...) :
For this purpose, the induction of
cyclooxygenase-2 (COX-2) , the production of the chemokine monocyte chemoattractant protein-1 ( MCP-1 ), and the
activation of the
nuclear factor kappa B (NF-kappa B) were studied
Nakao et al., Mol Cell Biochem 2002
:
Tumor necrosis factor alpha (TNF-alpha) induced prostaglandin E2 release is mediated by the
activation of
cyclooxygenase-2 (COX-2) transcription via
NFkappaB in human gingival fibroblasts
Tomita et al., Respirology 2002
:
Using a human airway cell line ( LC-2/ad ), lipopolysaccharide (LPS) induced gene expression of hBD-2 was studied in the absence or the presence of ( i ) dexamethasone, ( ii )
inhibition of
NF-kappaB and AP-1, ( iii ) intracellular calcium chelator, and ( iv )
cyclooxygenase (COX) inhibitors ... These findings suggest that glucocorticoids ( GC ), but not
COX inhibitors,
reduce hBD-2 gene expression, while
NF-kappaB , AP-1 and intracellular calcium are essential for hBD-2 expression
Surh et al., Ann N Y Acad Sci 2002
:
These ginsenosides also suppressed expression of
cyclooxygenase-2 (COX-2) and
activation of
NF-kappaB in the TPA treated dorsal skin of mice
Chiang et al., J Pharm Pharmacol 2003
:
We have investigated the
role of protein kinase C ( PKC ) and
nuclear factor-kappaB (NF-kappaB) in
cyclooxygenase-2 (COX-2) expression caused by Staphylococcus aureus lipoteichoic acid in RAW 264.7 macrophages
Yoneda et al., J Med Microbiol 2003
:
Following infection of HEp-2 cells with C. pneumoniae,
NF-kappa B was activated,
COX-2 was
induced and PGE ( 2 ) was elevated
Murakami et al., Cancer Lett 2003
:
Degradation of IkappaB ( IkappaB ) is a key step for
nuclear factor-kappaB (NF-kappaB) induced transcription of certain proinflammatory genes, including inducible nitric oxide synthase (iNOS) and
cyclooxygenase (COX)-2
Jung et al., FASEB J 2003
(Inflammation...) :
IL-1 mediated
NFkB dependent
cyclooxygenases-2 (COX-2) expression served as a positive effector for HIF-1alpha induction
Chen et al., Blood 2004
:
Inhibition of
nuclear factor-kappaB (NF-kappaB) and mitogen activated protein kinase ( MAPK ) pathway signaling by CsA may be responsible for the CsA mediated
effects on the regulation of chemokine receptor and
cyclooxygenase-2 (COX-2) expression
Kiritoshi et al., Diabetes 2003
(Diabetes Mellitus, Experimental...) :
Our results suggest that hyperglycemia increases mitochondrial ROS production, resulting in
NF-kappaB activation,
COX-2 mRNA
induction , COX-2 protein production, and PGE2 synthesis
Rao et al., J Biol Chem 2004
:
The increase in
COX 2 following GSK 3beta inhibition was entirely
blocked by
NFkappaB inhibition using mutant IkappaB adenovirus
Beak et al., Biochimie 2004
:
These results suggest that the NADPH oxidase and
COX may be major sources for the UVB induced ROS generation, and
play an essential role in the activation of
NF-kappaB which is involved in the expression of a variety of genes induced by UVB in HaCaT cells
Benito et al., Ann Rheum Dis 2005
(Disease Progression...) :
The inflammatory cell infiltrate, blood vessel formation, and angiogenic factors,
NF-kappaB activation , expression of tumour necrosis factor alpha (TNFalpha) and interleukin 1beta (IL1beta), and the presence of
cyclo-oxygenase (COX)-1 and COX-2 were quantified
Ackerman et al., Biol Reprod 2005
:
We and others have demonstrated an essential
role for
nuclear factor kappaB (NFkappaB) in cytokine-driven
COX2 expression
Kim et al., J Pharm Pharmacol 2005
(Disease Models, Animal...) :
Taken together, the data demonstrate that MEMO has anti-inflammatory and antinociceptive activity,
inhibiting iNOS,
COX-2 and TNF-alpha expression by down regulating
NF-kappaB binding activity
Jung et al., Mech Ageing Dev 2006
(Inflammation) :
NF-kappaB plays a key role in pro-inflammatory gene expression, such as
cyclooxygenase (COX)
Collino et al., Eur J Pharmacol 2006
(Brain Ischemia...) :
Pre-treatment with either rosiglitazone or pioglitazone significantly reduced oxidative stress,
COX-2 protein expression and
activation of MAPKs and
NF-kappaB
Ivanov et al., Exp Cell Res 2006
(Melanoma) :
We report here the use of a combination of sodium arsenite, an inhibitor of
NF-kappaB activation, and NS398, a
cyclooxygenase-2 (COX-2) inhibitor , for restoration of the surface FasL expression
Homhual et al., J Nat Prod 2006
:
Bruguierin A ( 1 ) also inhibited phorbol ester induced
NFkappaB ( nuclear factor-kappaB ) luciferase activation with an IC ( 50 ) value of 1.4 microM and selectively
inhibited cyclooxygenase-2 (COX-2) activity with an IC ( 50 ) value of 0.37 microM
Hardy et al., Mol Endocrinol 2006
(Inflammation) :
In the present study, we tested the hypothesis that progesterone/PR inhibits uterine contractility by blocking
nuclear factor kappaB (NF-kappaB) activation and
induction of
cyclooxygenase-2 (COX-2) , a contractile gene that is up-regulated in labor
Madrigal et al., CNS Neurol Disord Drug Targets 2006
(Atrophy) :
NFkappaB activation
results in the induction of iNOS and
COX2 , two enzymes responsible for a great portion of the neurological damage produced in models of stress
Mathew et al., Am J Respir Cell Mol Biol 2007
:
Macrophage activation was determined by measuring surface expression of CD11b,
activation of
NF-kappaB , phagocytic activity and production of reactive oxygen species, and
cyclooxygenase (COX)-2 gene expression and production of prostaglandins
Lee et al., J Biomed Sci 2008
(Colitis...) :
In addition, consumption of UDN glycoprotein attenuated the activities of proliferating cell nuclear antigen ( PCNA ), inducible nitric oxide synthase (iNOS), and
cyclooxygenase-2 (COX-2) , and
inhibited the DNA binding activities of
nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in the mice colonic tissue
Yokozawa et al., J Pharm Pharmacol 2007
(Disease Models, Animal...) :
Furthermore, it inhibited the
increase of
cyclooxygenase (COX)-2 with the regulation of
nuclear factorkappa B (NF-kappaB) and bcl-2 proteins in the liver, suggesting that the protective potential of Kangenkaryu extract against metabolic syndrome would be attributed to the regulation of COX-2, NF-kappaB, and bcl-2 signalling pathways
Travaglione et al., Infectious agents and cancer 2008
:
CNF1 is receiving an increasing attention as a putative factor involved in transformation because of its ability to : ( i ) induce
COX2 expression, an immediate-early gene over expressed in some type of cancers ; ( ii )
induce a long lasting activation of the transcription factor
NF-kB , a largely accepted marker of tumor cells ; ( iii ) protect epithelial cells from apoptosis ; ( iv ) ensue the release of pro-inflammatory cytokines in epithelial and endothelial cells ; and ( v ) promote cellular motility
Ye et al., Am J Physiol Heart Circ Physiol 2008
(Disease Models, Animal...) :
We investigated 1 ) whether 3-day ATV pretreatment limits IS in eNOS ( -/- ) and iNOS ( -/- ) mice and 2 ) whether
COX2 expression and/or activation by ATV is eNOS, iNOS, and/or
NF-kappaB dependent
Martins et al., Cell Physiol Biochem 2008
:
In the present study, we investigated the effect of insulin on the LPS induced production of nitric oxide ( NO ) and prostaglandin ( PG ) -E ( 2 ), on the expression of inducible nitric oxide synthase (iNOS) and
cyclooxygenase (COX)-2 , and on
nuclear factor kappa B (NF-kappaB) activation in AMs
Lee et al., J Cell Biochem 2009
:
H ( 2 ) O ( 2 ) increased
NF-kappaB phosphorylation to
induce an increase in the levels of
cyclooxygenase (COX)-2 proteins
Cho et al., American journal of physiology. Renal physiology 2009
(Disease Models, Animal...) :
The untreated CKD rats exhibited azotemia, hypertension, hypertriglyceridemia, proteinuria, glomerulosclerosis, tubulointerstitial damage, upregulation of MCP-1, plasminogen activator inhibitor-1 ( PAI-1 ), transforming growth factor ( TGF ) -beta,
cyclooxygenase (COX)-1 , COX-2, and NAD ( P ) H oxidase ( NOX-4, gp91(phox), p47(phox) and p22(phox) subunits ) and
activation of
NF-kappaB ( IkappaB phosphorylation )
Min et al., J Ethnopharmacol 2009
(Inflammation) :
Inflammatory makers, such as expression of pro-inflammatory cytokines and
cyclooxygenase (COX)-2 , and
activation of
nuclear factor-kappa B (NF-kappaB) , were measured by enzyme linked immunosorbent assays and immunoblot analyses
Shimpo et al., J Orthop Sci 2009
(Osteoarthritis) :
IL-1beta strongly increased the translocation of
NF-kappaB to the nucleus and the phosphorylation of extracellular-signal regulated kinase, p38, and c-Jun amino-terminal kinase ; but the up-regulation was not
inhibited by DEX or
COX inhibitors
Shan et al., J Biomed Biotechnol 2009
(Brain Injuries...) :
Interestingly, we found, PSPC decreased the expression level of glial fibrillary acidic protein (GFAP), inducible nitric oxide synthase (iNOS), and
cyclooxygenase-2 (COX-2) ,
inhibited nuclear translocation of
nuclear factor-kappaB (NF-kappaB) , increased the activity of copper/zinc superoxide dismutase ( Cu/Zn-SOD ) and catalase (CAT), and reduced the content of malondialdehyde ( MDA ), respectively
Moon et al., Int Immunopharmacol 2010
(Arthritis, Experimental...) :
Additionally, by altering
nuclear factor (NF)-kappaB transcription activity in FLSs, curcumin
inhibited PGE ( 2 ) production,
COX-2 expression, and MMP secretion
Ivanov et al., Cell Signal 2010
:
The
NF-kappaB dependent gene expression of IL8, IL6,
PTGS2/COX2 , TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 ( PGE2 ) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB dependent gene expression in bystander cells
Yasuda et al., Tohoku J Exp Med 2010
(Arthritis, Rheumatoid) :
Anti-CD44 antibody reversed the inhibitory effects of HA on the LPS mediated increase in PGE ( 2 ) production,
COX-2 induction, and
activation of
NF-kappaB
Wong et al., Circulation 1998
(Cardiomyopathy, Dilated...) :
Induction of
cyclooxygenase (COX) , the enzyme responsible for generating prostanoids,
requires activation of
nuclear factor-kappaB (NF-kappaB)