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GRAP2 — RELA

Text-mined interactions from Literome

Lim et al., J Neurochem 2000 (Glioma) : The p38 mitogen activated protein kinase inhibitor SB-203580 also suppressed the GMF activated NF-kappaB , suggesting the involvement of the p38 signal transduction cascade
Carter et al., J Biol Chem 2000 : We have shown that both the ERK and p38 mitogen activated protein ( MAP ) kinases are necessary for cytokine gene transcription and that the p38 MAP kinase is required for NF-kappaB-driven transcription, so we hypothesized that the MEK -- > ERK pathway regulated NF-kappaB-driven transcription as well
Shikhman et al., J Immunol 2001 : N-acetylglucosamine mediated inhibition of the IL-1beta response of human chondrocytes was not associated with the decreased inhibition of the mitogen activated protein kinases c-Jun N-terminal kinase, extracellular signal related kinase, and p38 , nor with activation of the transcription factor NF-kappaB
Won et al., Brain Res Mol Brain Res 2001 (Glioma) : In C6 glioma cells, the stimulation with lipopolysaccharide ( LPS ; 1 microg/ml ) evoked increases of nitric oxide ( NO ) production, NO synthase ( iNOS ) mRNA expression, phosphorylation of p38 mitogen activated protein kinase ( p-p38 ), and the activation of NF kappa B
Rahman et al., Blood 2003 (MAP Kinase Signaling System) : The treatment of RAW264 cells with TSA and NaB inhibited TNF-alpha induced nuclear translocation of NF-kappa B and sRANKL induced activation of p38 mitogen activated protein kinase ( MAPK ) signals
Shimada et al., Carcinogenesis 2003 (Prostatic Neoplasms) : Nuclear factor kappaB (NFkappaB) was activated by 2-ME and closely regulated by the mitogen activated protein kinase, p38
Ludwig et al., Oncogene 2003 : Overexpression of Grap-2 inhibits RET induced NF-kappaB activation, and cotransfection of Grap-2 significantly reduces focus formation induced by oncogenic RET in NIH 3T3 cells
Deva et al., J Immunol 2003 (MAP Kinase Signaling System) : That NF-kappaB up-regulates p38 ( MAPK ) is novel and is in contradiction to earlier reports in which NF-kappaB was shown to inhibit p38 ( MAPK )
Bai et al., Biochem Biophys Res Commun 2004 : H ( 2 ) O ( 2 ) treatment stimulated phospholipase C-gamma1 ( PLC-gamma1 ), extracellular signal regulated kinase 1/2 ( ERK1/2 ), and NF-kappaB signaling but inhibited p38 mitogen activated protein kinase ( MAPK ) activation
Schmid et al., Infect Immun 2004 (MAP Kinase Signaling System) : The Inv triggered beta1 integrin signaling involves the small GTPase Rac ; the activation of MAP kinases, such as p38 , MEK1, and JNK ; and the activation of the transcription factor NF-kappaB
Petlickovski et al., Blood 2005 (Leukemia, Lymphocytic, Chronic, B-Cell...) : This response was characterized by transient phosphorylation of extracellular signal related kinase ( ERK ) and Akt ( protein kinase B [ PKB ] ), lack of activation of c-JUN NH2-terminal kinase (JNK) and p38 mitogen activated protein kinase ( MAPK ), and variable activation of phospholipase Cgamma2 ( PLCgamma2 ) and nuclear factor-kappaB (NF-kappaB)
Uesugi et al., Brain Res 2006 : These results suggest that both MKK3/6-p38MAPK and MKK4-JNK pathways are important signaling cascades leading to the induction of TNFalpha in LPS stimulated microglia, but that NFkappaB itself is not required for this induction
Nonn et al., Carcinogenesis 2007 : We utilized the cytokines tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-1beta to increase p38 dependent nuclear factor kappa-B (NFkappaB) activation and expression of pro-inflammatory genes cyclooxygenase-2 (COX-2), IL-6 and IL-8 in normal prostatic epithelial cells
Xue et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid...) : Furthermore, APC directly suppressed the production of tumor necrosis factor (TNF) and the activation of NF-kappaB and MAP kinase p38 , and inhibitors of NF-kappaB or p38 reduced the production of MMP-9, suggesting that APC inhibits MMP-9 by blocking TNF, NF-kappaB, and p38
Ben-Othman et al., Mol Immunol 2008 (Leishmaniasis...) : This impairment was not due to MAPK deactivation as inhibition of ERK1/2 and p38MAPK , actually enhances the transcriptional activity of NF-kappaB in response to initial contact of Leishmania with the murine macrophagic cell line Raw264.7
Zare et al., J Leukoc Biol 2008 : In contrast, Plg production did not require NF-kappaB , was only partly down-regulated by p38 MAPK inhibitor, and was efficiently inhibited by insulin, indicating a different mechanism for its induction
Tang et al., J Exp Med 2008 (Bone Marrow Diseases...) : Activation of TAK1 by proinflammatory cytokines and T and B cell receptors induces the nuclear localization of nuclear factor kappaB (NF-kappaB) and the activation of c-Jun N-terminal kinase (JNK)/AP1 and P38 , which play important roles in mediating inflammation, immune responses, T and B cell activation, and epithelial cell survival
Shan et al., Int J Oncol 2009 (Urinary Bladder Neoplasms) : Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA binding activity in human bladder T24 cells
Song et al., Atherosclerosis 2009 (Coronary Artery Disease) : SAA time-dependently induced transient and significant upregulation of NF-kappaB1 mRNA ; inhibitor studies indicate that activation of NF-kappaB through the ERK1/2, p38 and JNK MAPKs and the PI3K pathway was involved
Ghosh et al., Toxicol Appl Pharmacol 2009 (MAP Kinase Signaling System) : Pre-treatment with SP600125 ( JNK inhibitor ) and SB203580 ( p38 MAPK inhibitor ) attenuated NF-kappaB and IKK phosphorylation indicating that p38 and JNK MAPKs are mainly involved in arsenic induced NF-kappaB activation
Rajaiya et al., Molecular vision 2009 (Adenoviridae Infections...) : Confocal microscopy showed that inhibitors of the p38 , JNK, and ERK pathways differentially inhibited NFkappaB nuclear translocation, while PP2, an inhibitor of Src family kinases, completely inhibited NFkappaB nuclear translocation
Kadoki et al., Int Immunol 2010 (Acquired Immunodeficiency Syndrome) : p38 mitogen activated protein kinase ( MAPK ) and nuclear factor kappa B (NF-kappaB) activation , but neither extracellular signal regulated kinase nor c-Jun N-terminal kinase activation, were required for the activation, because only inhibitors for p38 MAPK and NF-kappaB suppressed activation of HIV-1
Ibraim et al., Parasites & vectors 2013 : Nitric oxide and cytokine production, MAPKs ( ERK, p38 and JNK ) and NF-kB activation were evaluated