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IGFBP1 — PTH

Text-mined interactions from Literome

Rosen et al., J Clin Endocrinol Metab 1992 (Hip Fractures...) : Based on previous work, we speculate that production of the 24/25-kDa IGFBP , which in vitro is known to inhibit IGF-I- and IGF-II mediated osteoblast function, may be stimulated by PTH in patients with the syndrome of age related osteoporosis
Hassager et al., J Clin Endocrinol Metab 1992 : PTH increased a 29-kDa IGFBP apparent only in UMR 106-01 cell conditioned medium, whereas GH had no direct effect on IGFBP secretion in any of the osteoblast-like cells tested
Tørring et al., Endocrinology 1991 : Agents that elevate intracellular cAMP by different mechanisms [ ( Bu ) 2cAMP, forskolin, and isobutylmethylxanthine ] mimicked the effect of PTH and PTHrP on IGFBP synthesis ... In comparison, PTH did not stimulate IGFBP production in fibroblasts and ROS 17/2.8 cells, which secrete IGFBPs of 42,000, 38,000, 34,000, 28,000, and 24,000 Mr, but not of 29,000 Mr. The PTH-responsive IGFBPs from UMR cells were nonglycosylated proteins with preferential affinity for IGF-I over IGF-II