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CD79A — NFKB1
Text-mined interactions from Literome
Petro et al., J Biol Chem 2001
:
Moreover, activation of
NF-kappaB in
response to
BCR signaling is completely abolished in B cells deficient for PLC-gamma2
Bone et al., Int Immunol 2001
:
Nuclear
NF-kappaB is
induced in B cells by engagement of either the
BCR or CD40 or by stimulation with lipopolysaccharide (LPS)
Korus et al., Oncogene 2002
(MAP Kinase Signaling System) :
NF-kappaB activation by
Bcr is not mediated by nuclear translocation, but rather by p38 mitogen activated protein kinase ( MAPK ) -dependent modification of the RelA/p65 transactivation domain
Hanson et al., J Biol Chem 2003
:
Consistent with this, evidence has been presented that
NF kappa B activity is
required for Ras and
BCR-ABL to transform cells ... The data presented here indicate that
BCR-ABL expression in 32D myeloid cells or oncogenic Ras expression in murine fibroblasts
blocks the ability of tumor necrosis factor (TNF) to activate
NF kappa B
Lin et al., Semin Immunol 2004
(Lymphoma, B-Cell, Marginal Zone) :
Recent studies demonstrate that CARMA1, a scaffold protein, plays an essential role in mediating TCR- or
BCR induced
NF-kappaB activation by recruiting two adaptor proteins, Bcl10 and MALT1, to lipid rafts following stimulation of antigen receptors
Xing et al., J Exp Med 2005
:
G5pr(-/-) B cells did not show abnormalities in the
BCR mediated
activation of Erks and
NF-kappaB , cyclin D2 induction, or Akt activation
Pappu et al., Eur J Immunol 2006
:
NF-kappaB activation through
B cell receptor (BCR) ligation is critical for B cell development, survival and antigen mediated activation of B cells
Duncan et al., Mol Cancer Ther 2008
:
Additionally, we reported previously that
BCR-ABL activates the transcription factor
nuclear factor-kappaB (NF-kappaB) in a manner dependent on Ras and that inhibition of NF-kappaB by expression of a modified form of IkappaBalpha blocked BCR-ABL-driven tumor growth in a xenograft model ... These data indicate that blockage of
BCR-ABL induced
NF-kappaB activation via IkappaB kinase beta inhibition represents a potential new approach for treatment of Imatinib- or Dasatinib-resistant forms of chronic myelogenous leukemia
Schuman et al., Blood 2009
:
However, the role of TAK1 in
B-cell receptor (BCR) mediated
NF-kappaB activation and B-cell development is not clear ... Thus, TAK1 is critical for B-cell maturation and
BCR induced
NF-kappaB activation
Xiao et al., Clin Immunol 2009
(Glomerulonephritis, IGA) :
IgA-HMC conditioned medium up-regulated expression of ICAM-1, IL-6 and ATR1 and
activated NF-kappaB and ERK1/2 in PTEC
Hoek et al., J Immunol 2009
(Lymphopenia) :
Recent studies have shown that
BCR signaling positively
regulates NF-kappaB2 , suggesting BCR regulation of BR3 signaling
Colombo et al., PloS one 2012
(Lupus Erythematosus, Systemic...) :
The effect of LAIR1 ligation by specific monoclonal antibodies, collagen or collagen producing mesenchymal stromal cells from reactive lymph nodes or bone marrow on Ig production by pokeweed mitogen and
B cell receptor (BCR) mediated
NF-kB activation was assessed by ELISA and TransAM assay
Hamdane et al., Oncogene 1997
:
Activation of p65 NF-kappaB protein by p210BCR-ABL in a myeloid cell line (
P210BCR-ABL activates p65
NF-kappaB ) ... We have analysed the
effect of
p210BCR-ABL expression on
NF-kappaB activity in DA1 cells ( an IL-3 dependent murine myeloid progenitor cell line ) ... A specific
stimulation of
NF-kappaB activity by kinase-active wild-type
p210BCR-ABL has been evidenced by transcriptional activation assays