Gene interactions and pathways from curated databases and text-mining

◀ Back to ITGB1

ITGB1 — PTK2

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: PTK2 → Complex of ITGA10-ITGB1 (increases, ITGA10/ITGB1 Activity, PTK2 Activity)
    Evidence: The expression and action of integrins are predominantly localized to the focal adhesion complex as originally demonstrated in fibroblasts. Focal adhesion complexes are the structural connection between the ECM and the cytoskeleton. Here, transmembrane signaling is mediated by integrins that cluster with dozens of cytoskeletal proteins and signaling molecules. Interestingly, integrins not only convey signals from the ECM into the cell (outside-in), but also react to cytoplasmic alterations by al...
  • OpenBEL Selventa BEL large corpus: PTK2 → Complex of ITGA5-ITGB1 (increases, ITGA5/ITGB1 Activity) Bao et al., Mol Cell Biol 2002*
    Evidence: Upon attachment to fibronectin, ECV 304 cells transfected with dn Cdc42 or dn Rac1 mutants exhibited the phosphorylated form of FAK. FAK phosphorylated at Tyr397 appeared within 60 minutes and was detected even in the presence of dn Cdc42 or dn Rac1, indicating that these integrin-induced signaling components are still activated by attachment when Cdc42 and Rac1 are blocked.
  • OpenBEL Selventa BEL large corpus: PTK2 → ITGB1 (increases, ITGB1 Activity) Bao et al., Mol Cell Biol 2002*
    Evidence: Beta1 integrin reduced ICAM-1 expression in A904L cells expressing wild type Fak. In presence of dominant negative truncated form of Fak, VSV-FAT and VSV-FRNK, beta1 integrin failed to downregulate ICAM-1.
  • OpenBEL Selventa BEL large corpus: PTK2 → ITGB1 (increases, ITGB1 Activity, PTK2 Activity)
    Evidence: Downstream Signaling Mediator: FAK FAK is recruited to focal adhesion complexes. The clustering of integrins and formation of the focal adhesion complex can induce tyrosine phosphorylation of FAK, as can other stimuli (32, 54).
  • OpenBEL Selventa BEL large corpus: PTK2 → ITGB1 (increases, PTK2 Activity)
    Evidence: Downstream Signaling Mediator: FAK FAK is recruited to focal adhesion complexes. The clustering of integrins and formation of the focal adhesion complex can induce tyrosine phosphorylation of FAK, as can other stimuli (32, 54).
  • BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, collaborate)
  • BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → PIP2/Gelsolin complex (GSN) (actin filament polymerization, collaborate)
  • BioCarta ucalpain and friends in cell spread: FODRIN (SPTAN1) → Paxillin/FAK/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-PTK2-TLN1-SPTAN1-ITGA1-ITGB1-SRC-VIL2) (modification, collaborate)
  • BioCarta ucalpain and friends in cell spread: Calpain1 complex (CAPNS1-CAPN1) → Paxillin/FAK/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-PTK2-TLN1-SPTAN1-ITGA1-ITGB1-SRC-VIL2) (modification, activates)
  • BioCarta ucalpain and friends in cell spread: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → Paxillin/FAK/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-PTK2-TLN1-SPTAN1-ITGA1-ITGB1-SRC-VIL2) (modification, collaborate)
  • BioCarta integrin signaling pathway: None → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  • BioCarta integrin signaling pathway: Zyxin (ZYX) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  • BioCarta integrin signaling pathway: CSK → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  • BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  • BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → FAK (PTK2) (modification, collaborate)
  • BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → Tensin (TNS1) (modification, collaborate)
  • BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → FAK (PTK2) (modification, collaborate)
  • BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → NOLC1 (modification, collaborate)
  • BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → Calpain1 (CAPN1) (modification, collaborate)
  • BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → Actin (ACTA1) (modification, collaborate)
  • BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → utrophin (UTRN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: utrophin (UTRN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  • BioCarta pten dependent cell cycle arrest and apoptosis: Integrin-beta/SHC/SOS-1/GRB2 complex (ITGB1-SHC1-SOS1-GRB2) → FAK (PTK2) (modification, activates)
  • BioCarta mcalpain and friends in cell motility: Calpastatin (CAST) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, inhibits)
  • BioCarta mcalpain and friends in cell motility: Actin (ACTA1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, collaborate)
  • BioCarta mcalpain and friends in cell motility: Calpain1 complex (CAPNS1-CAPN1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, activates)
  • BioCarta mcalpain and friends in cell motility: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, collaborate)
  • BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: Rho-Kinase Dia/Profilin complex (PFN1-DIAPH1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) (actin filament polymerization, activates)
  • BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: Rho-Kinase Dia/Profilin complex (PFN1-DIAPH1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, activates)
  • BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, collaborate)
  • BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → Paxillin/FAK/Talin/MLC/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) (modification, collaborate)
  • BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → myosin light chain protein kinase (MYLK) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) → None (modification, activates)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) → None (modification, activates)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → cortactin (CTTN) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: cortactin (CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  • BioCarta mcalpain and friends in cell motility: Calpastatin (CAST) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, inhibits)
  • BioCarta mcalpain and friends in cell motility: Actin (ACTA1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, collaborate)
  • BioCarta mcalpain and friends in cell motility: Ezrin (VIL2) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, activates)
  • BioCarta mcalpain and friends in cell motility: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, collaborate)
  • BioCarta mcalpain and friends in cell motility: MLC (MLC1) → Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) (modification, collaborate)
  • BioCarta mcalpain and friends in cell motility: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) (modification, collaborate)
  • BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → Calpain2 complex (CAPNS1-CAPN2) (modification, collaborate)
  • BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B) (modification, collaborate)
  • BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → Calpastatin (CAST) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1) → Laminin (LAMA1/LAMC3/LAMA2/LAMB1/LAMC1/LAMB2/LAMA4/LAMA5/LAMC2/LAMB3/LAMA3) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  • BioCarta agrin in postsynaptic differentiation: Laminin (LAMA1/LAMC3/LAMA2/LAMB1/LAMC1/LAMB2/LAMA4/LAMA5/LAMC2/LAMB3/LAMA3) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  • BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, collaborate)
  • KEGG Axon guidance: ITGB1 → PTK2 (protein-protein, indirect effect)
  • KEGG Focal adhesion: ITGB1/ITGB3/ITGB4/ITGB5/ITGB6/ITGB7/ITGB8 → PTK2 (protein-protein, activation)
  • KEGG Regulation of actin cytoskeleton: ITGA1/ITGA10/ITGA11/ITGA2/ITGA2B/ITGA3/ITGA4/ITGA5/ITGA6/ITGA7/ITGA8/ITGA9/ITGAD/ITGAE/ITGAL/ITGAM/ITGAV/ITGAX/ITGB1/ITGB2/ITGB3/ITGB4/ITGB5/ITGB6/ITGB7/ITGB8 → Complex of BCAR1-CRK-CRKL-PTK2 (protein-protein, activation)
  • KEGG Pathways in cancer: Complex of ITGA2-ITGA2B-ITGA3-ITGA6-ITGAV-ITGB1 → PTK2 (protein-protein, activation)
  • KEGG Small cell lung cancer: Complex of ITGA2-ITGA2B-ITGA3-ITGA6-ITGAV-ITGB1 → PTK2 (protein-protein, activation)
  • NCI Pathway Database CXCR4-mediated signaling events: alpha-beta1 Integrin (ITGA8/ITGB1/ITGA10/ITGB1/ITGA6/ITGB1/ITGA1/ITGB1/ITGA3/ITGB1/ITGA2/ITGB1/ITGAV/ITGB1/ITGA11/ITGB1/ITGA4/ITGB1/ITGA7/ITGB1/ITGA5/ITGB1/ITGA9/ITGB1) → FAK/p130 Cas/Paxillin complex (PTK2-BCAR1-PXN) (cell adhesion, collaborate)
    Okabe et al., J Hematother Stem Cell Res 2002, Glodek et al., Leukemia 2007
    Evidence: mutant phenotype, assay
  • NCI Pathway Database Signaling events mediated by focal adhesion kinase: FAK (PTK2) → alpha5/beta1 Integrin complex (ITGA5-ITGB1) (modification, activates)
    Michael et al., Mol Biol Cell 2009*, Chen et al., J Biol Chem 1995*
    Evidence: assay, physical interaction
  • NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → FAK (PTK2) (modification, activates) Rose et al., J Immunol 2003, Nojima et al., Cell Immunol 1995*, Manie et al., Blood 1996
    Evidence: mutant phenotype

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Molina et al., J Dent Res 2001 : Mechanical stress has been shown in vitro to modulate integrin-beta1 mediated activation of p125FAK/FAK
Nojima et al., J Exp Med 1992 : Here, we report that the engagement of VLA-4 on T cells with specific antibodies or its ligand activates protein-tyrosine kinase ( PTK ) activity as detected by antiphosphotyrosine immunoblotting
Oostendorp et al., Leukemia & lymphoma 1997 : It has been demonstrated that ligation of VLA-4 induces phosphorylation of the protein tyrosine kinase ( PTK ) pp125FAK as well as other proteins which may be involved in the regulation of ligand affinity