Gene interactions and pathways from curated databases and text-mining

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CA2 — CFTR

Text-mined interactions from Literome

Atia et al., Pflugers Arch 1999 (Second Messenger Systems) : We speculate that not only cAMP but also cell Ca2+ plays a crucial role in the activation of CFTR in A6
Weber et al., Pflugers Arch 2001 (Cystic Fibrosis) : CFTR stimulation by cAMP-cocktail was independent of external Ca2+ and ATP had no additional activating potency
Boucherot et al., J Membr Biol 2001 : Thus, KCNQ1 expressed in Xenopus oocytes is regulated by cAMP and Ca2+ but is not affected by CFTR
Guerra et al., Pflugers Arch 2004 : These data suggest that the X laevis P2Y1 receptor in A6 cells can increase both cAMP/PKA and Ca2+/PKC intracellular levels and that the PKC pathway is involved in CFTR activation via potentiation of the PKA pathway
Hybiske et al., Am J Physiol Lung Cell Mol Physiol 2007 (Calcium Signaling...) : Effects of cystic fibrosis transmembrane conductance regulator and DeltaF508CFTR on inflammatory response, ER stress, and Ca2+ of airway epithelia