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CA2 — HGF

Text-mined interactions from Literome

Baffy et al., J Cell Physiol 1992 : Preincubation of cells with 10 microM of genistein to inhibit protein tyrosine kinases abolished the HGF induced Ca2+ response and also inhibited HGF induced Ins 1,4,5-P3 production in rat liver cells
Kaneko et al., Hepatology 1992 (Second Messenger Systems) : The Ca2+ response to human hepatocyte growth factor was dose dependent ; 10 ( -10 ) mol/L hHGF gave the highest Ca2+ response, similar to the dose-response curve of DNA synthesis
Mine et al., Biochem Biophys Res Commun 1991 : We compared the effects of HGF and EGF on cytoplasmic free calcium concentration, [Ca2+ ] c, and inositol trisphosphate production in rat hepatocytes
Kawanishi et al., Cell Calcium 1995 : HGF ( 40 ng/ml ) increased cytosolic free Ca2+ concentration ([Ca2+]i) in about 60 % of hepatocytes, in 45 % of which the increases were oscillatory
Saso et al., Alcohol Clin Exp Res 1996 : HGF stimulation of liver cells causes formation of inositol 1,4,5-triphosphate, which releases Ca2+ from intracellular Ca2+ ([Ca2+]i) stores, and causes elevation of cytosolic Ca2+ levels ... The Ca2+ response induced by HGF ( 0.3 to 5 ng/ml ) was inhibited by EtOH, with an EC50 of approximately 50 mM
Gulati et al., Endocrinology 1997 : HGF/SF decreased cell contact within 1 h, increased [ Ca2+ ] i levels by 3 h, and induced apoptosis by 6 h of culture ... This concept is based on the observations that : 1 ) in the presence of the calcium chelator BAPTA, HGF/SF decreased cell contact but did not increase [ Ca2+ ] i or apoptosis ; 2 ) bFGF blocked HGF/SF induced increase in [ Ca2+ ] i ; 3 ) bFGF did not attenuate HGF/SF 's apoptotic action if exposed to cells after the increase in [ Ca2+ ] i ; and 4 ) RNA and protein synthesis were required for HGF/SF to increase [ Ca2+ ] i, whereas the thapsigargin- and Bay K-induced increase in [ Ca2+ ] i and apoptosis were independent of RNA/protein synthesis