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CA2 — PLA2G4A
Text-mined interactions from Literome
Pedersen et al., Eur J Biochem 2000
(Carcinoma, Ehrlich Tumor) :
Stimulation by either hypotonic cell swelling or addition of the
Ca2+ ionophore A23187
results in translocation of
cPLA2alpha , but not cPLA2gamma, to the nucleus, where it forms hot-spot-like clusters
Kitatani et al., Arch Biochem Biophys 2000
:
The effect of ceramide on
Ca2+ dependent translocation of
cytosolic phospholipase A2 (cPLA2) to membranes was studied ... Sphingomyelinase and C6-ceramide, but not C6-dihydroceramide, a control analog of C6-ceramide, also facilitated the
Ca2+ dependent increase in the
cPLA2 protein, as well as the activity, in membranes induced by addition of Ca2+ into platelet lysate ... These findings suggest that ceramide in membranes potentiates
Ca2+ dependent
cPLA2 translocation from cytosol to membranes, probably through modification of membrane phospholipid organization
Kifor et al., American journal of physiology. Renal physiology 2001
(MAP Kinase Signaling System) :
High
Ca2+o increased serine phosphorylation of the 85-kDa
cytosolic phospholipase A2 (cPLA2) in both parathyroid and HEKCaR cells
Siegel et al., J Biol Chem 2001
(Calcium Signaling...) :
In the present study we have investigated the role of
cytosolic phospholipase A2 (cPLA2) and AA in acetylcholine (ACh)- and bombesin
induced Ca2+ signaling
Fatima et al., J Pharmacol Exp Ther 2001
:
SB203580 induced
cPLA2 phosphorylation was
inhibited by depletion of
Ca2+ from the medium, by the voltage operated Ca2+ channel blocker nifedipine, and by the calmodulin inhibitor W-7
Murakami et al., J Biochem 2002
:
Intracellular activation of
cPLA2alpha is tightly
regulated by
Ca2+ and phosphorylation
Kim et al., Prostaglandins Leukot Essent Fatty Acids 2001
:
The epidermal
cPLA2 is
Ca2+ dependent , active at micromolar concentration of Ca2+ and resistant to disulfide reducing agents
Kudo et al., Prostaglandins Other Lipid Mediat 2002
(Arteriosclerosis...) :
The activation of
cPLA2alpha is tightly
regulated by
Ca2+ and phosphorylation
Hirabayashi et al., Biol Pharm Bull 2004
:
Ca2+ binding
induces translocation of
cPLA2alpha from the cytosol to the perinuclear membranes
Gentili et al., J Cell Biochem 2004
:
Intracellular Ca2+ chelation ( BAPTA-AM, 5 microM ) suppressed the serine phosphorylation of cPLA2 in both, young and aged rats, demonstrating that intracellular
Ca2+ is
required for full activation of
cPLA2 in enterocytes stimulated with PTH
Luo et al., Cell Signal 2006
(MAP Kinase Signaling System) :
LPS induced expression of
cPLA2 and release of PGE2 was
attenuated by inhibitors of tyrosine kinase ( genistein ), phosphatidylcholine-phospholipase C ( D609 ), phosphatidylinositol-phospholipase C ( U73122 ), PKC ( GF109203X and staurosporine ), removal of
Ca2+ by BAPTA/AM plus EDTA, MEK1/2 ( PD98059 ), p38 ( SB202190 ), JNK ( SP600125 ), and phosphatidylinositol 3-kinase ( PI3-K ; LY294002 and wortmannin )
Nakamura et al., Biochem Pharmacol 2006
:
C1P increased the enzymatic activity of
cPLA2alpha over two-fold in the
presence of
Ca2+
Olsson et al., Journal of inflammation (London, England) 2006
:
Cytosolic phospholipase A2 is a major down-stream target and this enzyme is
regulated by both phosphorylation and an increase in intracellular
Ca2+
Liu et al., FEBS Lett 2006
(Calcium Signaling) :
We conclude that in A7r5 cells vasopressin stimulates AA release via a
Ca2+ dependent activation of
cPLA2
Taniguchi et al., Biochem Pharmacol 2007
:
Our data show that Na3VO4 stimulates AA release largely via
cPLA2alpha activation in
Ca2+ dependent manner, and the cross-talk between Src and PKC and the ERK dependent pathways are involved in Na3VO4 induced AA release from L929 cells
St-Onge et al., Biochim Biophys Acta 2007
:
We found that the
Ca2+ dependent type IV
cytosolic phospholipase A2 (cPLA2) was pivotally involved in the COX-2 mediated generation of PGE2 in response to a calcium ionophore, as determined by the use of selected PLA2 inhibitors
Persaud et al., Arch Physiol Biochem 2007
:
Arachidonic acid ( AA ) is generated in pancreatic beta-cells through the activation of
Ca2+ dependent
cytosolic phospholipase A2 (cPLA2) and the consequent hydrolysis of membrane phospholipids in the sn-2 position of the glycerophospholipid backbone
Murray-Whelan et al., Eur J Biochem 1995
:
We addressed the possibility that the
activation of
cPLA2 by
Ca2+ and/or protein kinase C is dependent on G alpha i2 ... specifically inhibits
Ca2+ activation of
cPLA2
Nalefski et al., J Biol Chem 1994
:
Cytosolic phospholipase A2 (cPLA2) associates with natural membranes in
response to physiological increases in
Ca2+ , resulting in the selective hydrolysis of arachidonyl phospholipids
Kramer et al., J Biol Chem 1993
:
We conclude that 1 ) cPLA2 is likely to play an important role in agonist induced mobilization of arachidonic acid and 2 ) thrombin elicits rapid and full activation of cPLA2 not only by promoting a rise in cytosolic free
Ca2+ but also by
inducing phosphorylation of
cPLA2 thereby improving its catalytic activity
Reynolds et al., Biochim Biophys Acta 1993
:
Using a pure recombinant enzyme, we have confirmed that
cPLA2 is not absolutely
dependent on
Ca2+ , since Sr2+, Ba2+ and Mn2+ also gave full enzyme activity
Clark et al., J Lipid Mediat Cell Signal 1995
:
Therefore, full activation of
cPLA2 requires both increased cytosolic
Ca2+ and cPLA2 phosphorylation at Ser-505
Muthalif et al., J Biol Chem 1996
:
Activation of adrenergic receptors with NE in VSMC caused translocation of CaM kinase II, MAP kinase, and
cPLA2 to the nuclear envelope only in the
presence of extracellular
Ca2+
Berguerand et al., Am J Respir Cell Mol Biol 1997
(Cystic Fibrosis) :
As the binding of
cPLA2 to membranes is
Ca2+ dependent , the increased coupling to PLC could cause the hypersensitivity to bradykinin
Crawford et al., Mol Biol Cell 1998
:
Although translocation of
cPLA2 from cytosol to membrane was
Ca2+ dependent , phosphorylation of cPLA2 was attachment dependent and could occur both on the membrane and in the cytosol
Zhang et al., Eur J Pharmacol 1999
:
In the present study, we investigated the involvement of Ca2+ signaling and protein kinases in the
effect of
Ca2+-ATPase inhibitors on the activation of
cytosolic phospholipase A2 (cPLA2) in human polymorphonuclear neutrophils
Hirabayashi et al., J Biol Chem 1999
(Calcium Signaling) :
A
Ca2+ regulated
cytosolic phospholipase A2 (cPLA2) plays a dominant role in the release of AA