◀ Back to CD40
APCS — CD40
Text-mined interactions from Literome
Häcker et al., J Exp Med 2000
:
Signal transduction via molecules of the Toll-like receptor ( TLR ) /interleukin 1 receptor (IL-1R) pathway is critical for
activation of
APCs either by pathogen derived pattern ligands like lipopolysaccharides (LPS) or by
CD40 ligation through T helper cells
Amrani et al., Immunity 2002
(Diabetes Mellitus, Type 1) :
These results demonstrate the existence of a novel, CD154 dependent pathway of CD4 ( + ) T cell activation that is independent of
CD40 mediated activation of
APCs
Dotti et al., Blood 2002
(Plasmacytoma) :
Because expression of CD40L gave equivalent protection from CD40 ( + ) and CD40 ( - ) tumors and transgenic-CD40L failed to up-regulate costimulatory molecules in either tumor, the protective effects of CD40L probably resulted from recruitment/activation of professional
APCs rather than from
CD40 activation of plasmacytoma cells
Ichikawa et al., J Immunol 2002
(Disease Susceptibility...) :
Activation of
APCs through
CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease ... We hypothesized that tolerance against candidate autoantigens could be reversed by
activation of
APCs via
CD40 or Toll-like receptor 9 signaling
Hewitson et al., J Immunol 2006
(Helminthiasis) :
In this study, using CD154-/- mice exposed to radiation attenuated S. mansoni larvae, we demonstrate
roles for
CD154/CD40 in the activation of skin derived
APCs and the development of Th1 cells in the skin draining lymph nodes ( sdLN )
Feau et al., Nat Immunol 2011
(Listeriosis) :
Two competing theories have been put forward to explain the role of CD4 ( + ) T cells in priming CD8 ( + ) memory T cells : one proposes paracrine secretion of interleukin 2 (IL-2) ; the other proposes the
activation of
antigen presenting cells (APCs) via the costimulatory molecule
CD40 and its ligand CD40L
Naito et al., Cancer Immunol Immunother 2013
(Leukemia, Lymphocytic, Chronic, B-Cell) :
In addition,
CD40L-Tri could
induce malignant B cells to become effective
APCs , such that tumor directed immune responses could be probed
Mendoza et al., J Immunol 1997
(Mast-Cell Sarcoma) :
Interaction of
CD40 with its ligand ( CD154 ) can
induce CD40 bearing
APCs to express immune stimulatory accessory molecules that facilitate immune recognition