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CD40 — IKBKG

Pathways - manually collected, often from reviews:

• WikiPathways NLR Proteins: IKBKG/CHUK/IKBKB → Complex of RELA-CD40 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: Complex of 82 proteins (in vivo) Matsuzawa et al., Science 2008
• STRING interaction: IKBKG — CD40 (interaction, mapped from grid)
• STRING interaction: CD40 — IKBKG (interaction, mapped from grid)

Text-mined interactions from Literome

Manning et al., Eur J Immunol 2002 : Engagement of CD40 by its ligand induces IKK and mitogen activated protein kinase ( MAPK ) phosphorylation and transcriptional activation, leading to activation and differentiation of B cells
Ho et al., Blood 2005 (Lymphoma, B-Cell...) : API2-MALT1 and exogenous MALT1 increased constitutive NF-kappa B activity and enhanced I kappa B kinase (IKK) activation induced by CD40 stimulation
Mukundan et al., J Immunol 2005 : Finally, treatment of monocytes with a cell-permeable peptide corresponding to the TRAF6 binding motif of CD40 inhibited CD40 activation of ERK1/2, IKK , and inflammatory cytokine production
Taguchi et al., Genes Cells 2009 : TRAF6 is essential for osteoclastogenesis and for both RANK- and CD40 mediated activation of IKK and MAPKs