UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to PDGFB

FYN — PDGFB

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: FYN → Complex of PDGFB-PDGFB (increases, PDGFB/PDGFB Activity)
Evidence: exposure to PDGF resulted in a marked increase in c-Src, Fyn, and Yes kinase activities
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
Manes et al., Mol Cell Biol 2000, Blake et al., Mol Cell Biol 2000, Zhao et al., Mol Cell Biol 2006, Kypta et al., Cell 1990, Sirvent et al., Oncogene 2008, Ouyang et al., Proc Natl Acad Sci U S A 2008, Ralston et al., Proc Natl Acad Sci U S A 1985, Barone et al., Nature 1995, Alonso et al., J Biol Chem 1995, Hansen et al., Biochem Biophys Res Commun 1997, Roche et al., Curr Biol 1998
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
Wang et al., Oncogene 2000, Bowman et al., Proc Natl Acad Sci U S A 2001, Cirri et al., Biochem Biophys Res Commun 1997, Valgeirsdóttir et al., Oncogene 1998
Evidence: mutant phenotype
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → PDGF-BB/PDGFRB (dimer)/RasGAP/Src Family Kinases complex (PDGFRB-RASA1-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-PDGFB) (modification, collaborate)
Schlesinger et al., Biochem J 1999
Evidence: physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
Schlesinger et al., Biochem J 1999
Evidence: physical interaction
NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP/Src Family Kinases complex (PDGFRB-RASA1-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-PDGFB) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
Schlesinger et al., Biochem J 1999
Evidence: physical interaction