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EGFR — NOTCH3

Text-mined interactions from Literome

Li et al., J Biol Chem 2007 (Skin Neoplasms) : Interestingly, the up-regulation of EGFR is independent of Notch signaling, suggesting that the EGFR pathway functions in parallel with Notch in the tumorigenesis of SCC
Osipo et al., Oncogene 2008 (Breast Neoplasms) : Trastuzumab or a dual epidermal growth factor receptor (EGFR)/ErbB-2 tyrosine kinase inhibitor ( TKI ) increased Notch activity by 2- to 6-fold in SKBr3, BT474 and MCF-7/HER2-18 cells
Aguirre et al., Nature 2010 : This occurs through a non-cell-autonomous mechanism involving EGFR mediated regulation of Notch signalling