◀ Back to TNF

BAX — TNF

Text-mined interactions from Literome

Doman et al., J Interferon Cytokine Res 1999 : TNF also stimulated p53, p21WAF1, and Bax accumulation with subsequent PARP cleavage and nucleosomal DNA laddering in MCF-7 cells but did not stimulate these processes in MCF-7/3E9 cells
Katschinski et al., Cancer Res 1999 (Fever...) : The threshold temperature for the onset of apoptosis was 42 degrees C. Whereas hyperthermia exerted no effect on the expression of Bcl-2 and Bax , heat induced a > 30-fold increase of tumor necrosis factor (TNF) alpha mRNA expression and a significant increase in TNF-alpha protein secretion
Kobayashi et al., Cytokine 2000 (Colonic Neoplasms) : TNF-alpha induced p21 ( WAF1 ) but not Bax in colon cancer cells WiDr with mutated p53 : important role of protein stabilization ... However, TNF-alpha did not affect the levels of the Bax protein, which also has p53 binding sites on its promoter and causes apoptosis
Sundararajan et al., J Virol 2001 (Adenoviridae Infections) : E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha mediated apoptosis ... TNF-alpha and truncated Bid induced Bax-Bax cross linking, indicative of oligomerization, and E1B 19K expression during infection inhibited this TNF-alpha mediated Bax oligomerization
Sundararajan et al., J Biol Chem 2001 : Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K ... TNF-alpha induces E1B 19K-Bax interaction and inhibits Bax oligomerization
Marselli et al., J Clin Endocrinol Metab 2001 : IL-1beta, interferon gamma, and TNF alpha caused no major change in either islet cell survival or Bcl-2 and Bax mRNA expression after a 12-h incubation ; however, a marked increase in the amount of dead cells, with a major decrease of Bcl-2 mRNA expression, was observed after 72 h
Kim et al., Carcinogenesis 2002 : TNF-alpha potentiated the cadmium induced accumulation of p53 but did not affect expression levels of Bax , Mdm2 and p21 ( WAF/CIP )
Zhang et al., Circ Res 2004 : We further show that a JNK-specific inhibitor SP600125 completely blocks TNF induced JNK activation, Bid cleavage, and Bax mitochondrial translocation, but only partially inhibits cytochrome c release and EC death, suggesting that TNF induces both JNK dependent and JNK independent apoptotic pathways in EC
Ramana et al., FEBS Lett 2004 : Inhibition of AR by sorbinil or tolrestat prevented TNF-alpha induced increase in Bax and Bak and the downregulation of Bcl-2
Birbes et al., Biochem J 2005 : A mitochondrial pool of sphingomyelin is involved in TNFalpha induced Bax translocation to mitochondria
Wang et al., Clin Cancer Res 2005 (Breast Neoplasms...) : Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted TNF-alpha induced stability of p53, up-regulation of phospho-p53ser15, p21waf/cip, and Bax , and down-regulation of Bcl-2 and Bcl-xL, which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing
Huang et al., Acta Med Okayama 2005 (Fibrosarcoma...) : In addition, z-VAD-fmk plus TNFalpha increased Bax expression without affecting Bcl-2 and cytochrome expression
Leroy et al., Biol Reprod 2007 (Inflammation) : Exogenous TNF mimicked LPS treated choriodecidua conditioned medium in that it induced myometrial cell apoptosis, reduced BCL2 expression, and increased BAX expression
Dey et al., J Neurochem 2007 : Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons through TNF-alpha mediated induction of Bax and phosphorylated c-Jun NH ( 2 ) -terminal kinase ... However, both cocaine and TNF-alpha independently increased phospho-c-Jun NH ( 2 ) -terminal kinase and Bax levels at concurrent time periods ( 30 min and 1 h ), and this elevation was attenuated in the presence of nTNF-alpha
Simmons et al., Oncogene 2008 : We also show that Bfl-1 blocks tumor necrosis factor-alpha (TNFalpha) induced activation of Bax indirectly, via association with tBid
Dhingra et al., Am J Physiol Heart Circ Physiol 2007 : The antioxidant Trolox modulated TNF-alpha induced changes in Bax/Bcl-xl , cell injury, and MAPKs
Sass et al., J Immunol 2007 (Disease Models, Animal...) : The underlying mechanism of protection seems to involve a cascade of events, where TNF induces the expression of A20 in hepatocytes, A20 down-modulates Bax expression by interference with transcriptional activation, and the reduced availability of Bax interferes with the onset of mitochondrial apoptosis and the ensuing apoptotic liver damage
Hou et al., Yao Xue Xue Bao 2007 (Breast Neoplasms) : [ Effect of Bax translocation on TNFalpha induced apoptosis of human breast cancer MCF7 cells stably expressed hGFP-Bax ]
Dinh et al., Neuroscience 2008 : DXMb protects the organ of Corti against TNFalpha ototoxicity by up-regulating Bcl-2 and Bcl-xl expression and by inhibiting TNFalpha induced increases in Bax , TNFR1, and the Bax/Bcl-2 ratio
Guan et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2009 : The results suggest that HeLa apoptosis was induced by tumor necrosis factor-a and interferon -gamma, and the increasing expression of P53 may induce the expression of Bax and prevent the expression of Bcl-2, via the mitochondrial induction of cell apoptosis
Zhang et al., World J Gastroenterol 2009 (Jaundice, Obstructive) : Radix Astragali has protective effects on immune organs of OJ rats by relieving the pathological changes in immune organs, reducing TNF-alpha level and inhibiting Bax expression and apoptosis in spleen and thymus
Bai-Feng et al., Diabetes Res Clin Pract 2010 : The expression of iNOS and the promoting apoptosis gene Bax and Fas were significantly up-regulated by the induction of IL-1beta and TNF-alpha
Al-Shudiefat et al., Mol Cell Biochem 2013 (Heart Diseases) : TNF-a also caused a significant increase in the expression of apoptotic proteins Bax , Caspase 3 and PARP cleavage, Bnip3, and TGF-ß, whereas OA modulated these changes