Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
FANCD2
→
ATM
(directlyIncreases, FANCD2 Activity)
Evidence: There is evidence that FANCD2,like BRCA1, participates in the events that are triggered by DNA damage during S and G2 phases and that lead to cell-cycle arrest. As well as modifying BRCA1, the ATM protein kinase can phosphorylate FANCD2 on several residues, including serine 222, following exposure to ionizing radiation77. Ser222 phosphorylation is required for the intra-S-phase arrest and is, in turn, dependent on the protein kinase NBS1, which is a component of the trimeric MRE11-RAD50-NBS1 com...