◀ Back to RAC1
EFNA1 — RAC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database EPHA2 forward signaling:
RAC1/GTP complex (RAC1)
→
Ephrin A1/EPHA2 complex (EFNA1-EPHA2)
(modification, collaborate)
Deroanne et al., J Cell Sci 2003*
Evidence: assay, other species
-
NCI Pathway Database EPHA2 forward signaling:
RAC1/GDP complex (RAC1)
→
Ephrin A1/EPHA2/Tiam1 complex (EFNA1-EPHA2-TIAM1)
(modification, collaborate)
Tanaka et al., EMBO J 2004
Evidence: mutant phenotype, assay
-
NCI Pathway Database EPHA2 forward signaling:
RAC1/GTP complex (RAC1)
→
Ephrin A1/EPHA2 complex (EFNA1-EPHA2)
(endocytosis, activates)
Zhuang et al., J Biol Chem 2007*
Evidence: mutant phenotype, assay
-
NCI Pathway Database EPHA2 forward signaling:
RAC1/GDP complex (RAC1)
→
Ephrin A1/EPHA2/VAV2-VAV3 complex (EFNA1-EPHA2-VAV2_VAV3)
(modification, collaborate)
Hunter et al., Mol Cell Biol 2006, Fang et al., J Biol Chem 2008
Evidence: mutant phenotype, assay
-
Reactome Reaction:
EFNA1
→
RAC1
(reaction)
Marston et al., Nat Cell Biol 2003, Yoo et al., Mol Cells 2010
-
Reactome Reaction:
EFNA1
→
RAC1
(indirect_complex)
Marston et al., Nat Cell Biol 2003
Text-mined interactions from Literome
Miao et al., J Cell Biol 2003
:
Ephrin-A1 suppressed HGF induced activation of
Rac1 and p21 activated kinase, whereas RhoA activation was retained, leading to the preservation of stress fibers
Brantley-Sieders et al., J Cell Sci 2004
(Neovascularization, Pathologic) :
Ephrin-A1 stimulation
induces PI3-kinase dependent activation of
Rac1 in wild-type endothelial cells, whereas EphA2-deficient cells fail to activate Rac1 upon stimulation
Hunter et al., Mol Cell Biol 2006
:
Overexpression of either Vav2 or Vav3 in primary microvascular endothelial cells promotes
Rac1 activation, cell migration, and assembly in
response to
ephrin-A1 stimulation ... Conversely, loss of Vav2 and Vav3 GEFs inhibits
Rac1 activation and
ephrin-A1 induced angiogenic
responses both in vitro and in vivo
Zhuang et al., J Biol Chem 2007
:
Ephrin-A1 stimulation activates Rac1 GTPase, and the
Rac1-GTP levels are further
increased in SHIP2 knockdown cells
Buricchi et al., Cell Adh Migr 2007
:
We identify redox circuitry in which the
ephrinA1 mediated inhibition of
Rac1 leads to a negative regulation of integrin redox signaling affecting the activity of the tyrosine phosphatase LMW-PTP
Takeuchi et al., FEBS Lett 2009
:
We found that the RacGAP beta2-chimaerin ( chimerin ) bound to EphA2 and EphA4 and inactivated
Rac1 in
response to
ephrinA1 stimulation