Kovacs et al., J Biol Chem 2002
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We report that homophilic cadherin ligation recruits Rac to nascent adhesive contacts and specifically stimulates Rac signaling
Goodwin et al., J Biol Chem 2003
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Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase : direct evidence of a role for cadherin activated Rac signaling in adhesion and contact formation ... These data provide direct evidence for a role of cadherin activated Rac signaling in contact formation and adhesive stabilization
Fukuyama et al., Oncogene 2006
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Activation of Rac by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway ... However, it has not fully been understood how cadherin induces the activation of Rac Matsuda et al., J Mol Cell Cardiol 2006
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RhoA and Rac1 activation was inhibited by the transfection of dominant negative N-cadherin , indicating that RhoA and Rac1 were activated by N-cadherin in the oriented cardiac myocytes
Kraemer et al., Am J Physiol Cell Physiol 2007
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To pursue upstream elements of the Rac1 signaling pathway, we focused on the potential contribution of Tiam1 to cadherin activated Rac signaling