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IGF1 — RAC1

Text-mined interactions from Literome

Okamoto et al., Mol Cell Biol 2000 : Both S1P and IGF I induced a biphasic increase in the amount of the GTP bound active form of Rac ... In EDG5 cells, S1P stimulated PI 3-kinase activity as it did in EDG1 cells but inhibited the basal Rac activity and totally abolished IGF I-induced Rac activation, which involved stimulation of Rac-GTPase activating protein activity rather than inhibition of Rac-guanine nucleotide exchange activity
Nagasawa et al., Biochem J 2005 : EP2 stimulation failed to inhibit tyrosine phosphorylation either of IGF-I receptor or IRS-1 ( insulin receptor substrate-1 ), or activation of phosphoinositide 3-kinase or Akt in response to IGF-I, but potently and dose-dependently inhibited IGF-I induced activation of cellular Rac activity and membrane ruffling ... The inhibitory effects of PGE2 on IGF-I induced chemotaxis, membrane ruffling and Rac activation were faithfully reproduced by a low concentration of forskolin, which induced a comparable extent of cAMP elevation as with 10 ( -8 ) M PGE2, and were potentiated by isobutylmethylxanthine
Ceacareanu et al., Am J Physiol Cell Physiol 2006 : The present study was performed to investigate the hypotheses that 1 ) IGF-I increases the activity of the small GTPase Rac1 as well as H(2)O ( 2 ) levels and 2 ) NO suppresses IGF-I induced H ( 2 ) O ( 2 ) elevation by decreasing Rac1 activity via increased PTP-PEST activity and dephosphorylation of p130 ( cas ) ... We report that IGF-I induces phosphorylation of p130 ( cas ) and activation of Rac1 and that NO attenuates these effects
Meng et al., Cardiovasc Res 2008 : Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells ... IGF-I induced the activation of Rac1 ... Knockdown of Nox4 did not affect IGF-I induced activation of Rac1
Morimura et al., International journal of cell biology 2011 : In noninvasive breast cancer MCF7 cells, no lamellipodia were induced by IGF-I , whereas in MDA-MB-231 cells, Rac1 , stathmin, and EB1 were overexpressed