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PDGFB — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database PDGFR-beta signaling pathway: RAC1/GTP complex (RAC1) → PDGF-BB/PDGFRB (dimer)/GAB1/N-WASP/NCK1-2 complex (PDGFRB-GAB1-WASL-NCK2_NCK1-PDGFB) (modification, activates)
  Abella et al., J Cell Sci 2010
  Evidence: mutant phenotype, assay
• NCI Pathway Database PDGFR-beta signaling pathway: RAC1/GDP complex (RAC1) → PDGF-BB/PDGFRB (dimer)/GAB1/N-WASP/NCK1-2 complex (PDGFRB-GAB1-WASL-NCK2_NCK1-PDGFB) (modification, collaborate)
  Kallin et al., J Biol Chem 2004, Abella et al., J Cell Sci 2010
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Ryu et al., Circ Res 2002 : In rat and human aortic SMCs, the chemoattractant platelet derived growth factor B-chain ( PDGF ) induced rapid 5- to 6-fold increases in the cellular amount of GTP bound, active form of Rac
Yuan et al., Clin Exp Metastasis 2010 (Brain Neoplasms...) : Herein we demonstrate that PDGF-BB treatment of MB cells induces concomitant activation of PDGFRß, MEK1/ERK, Rac1 and Pak1, but suppresses Rho activity, which together significantly promotes cell migration