BioCarta ucalpain and friends in cell spread:
RAC1
→
Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2)
(modification, activates)
BioCarta ucalpain and friends in cell spread:
Talin (TLN1)
→
Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2)
(modification, collaborate)
BioCarta ucalpain and friends in cell spread:
Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2)
→
Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1)
(modification, collaborate)
BioCarta ucalpain and friends in cell spread:
Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2)
→
FODRIN (SPTAN1)
(modification, collaborate)
BioCarta ucalpain and friends in cell spread:
Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2)
→
Actin (ACTA1)
(modification, collaborate)
BioCarta ucalpain and friends in cell spread:
Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2)
→
Ezrin (VIL2)
(modification, collaborate)
BioCarta ucalpain and friends in cell spread:
Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2)
→
alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4)
(modification, collaborate)
BioCarta ucalpain and friends in cell spread:
Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2)
→
PAX (PXN)
(modification, collaborate)
BioCarta ucalpain and friends in cell spread:
Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1)
→
PAX (PXN)
(modification, collaborate)
BioCarta mcalpain and friends in cell motility:
Calpastatin (CAST)
→
Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1)
(modification, inhibits)
BioCarta mcalpain and friends in cell motility:
Actin (ACTA1)
→
Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1)
(modification, collaborate)
BioCarta mcalpain and friends in cell motility:
Ezrin (VIL2)
→
Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1)
(modification, activates)
BioCarta mcalpain and friends in cell motility:
Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1)
→
Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1)
(modification, collaborate)
BioCarta mcalpain and friends in cell motility:
MLC (MLC1)
→
Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1)
(modification, collaborate)
BioCarta mcalpain and friends in cell motility:
Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1)
→
Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1)
(modification, collaborate)
BioCarta mcalpain and friends in cell motility:
Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1)
→
Calpain2 complex (CAPNS1-CAPN2)
(modification, collaborate)
BioCarta mcalpain and friends in cell motility:
Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1)
→
PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B)
(modification, collaborate)
BioCarta mcalpain and friends in cell motility:
Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1)
→
Calpastatin (CAST)
(modification, collaborate)