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LDLR — TNF

Text-mined interactions from Literome

Hamanaka et al., J Biol Chem 1992 : Induction of low density lipoprotein receptor and a transcription factor SP-1 by tumor necrosis factor in human microvascular endothelial cells ... TNF-alpha induced enhancement of LDL receptor gene expression was not observed when cycloheximide was present ... The induction of LDL receptor by TNF might be mediated through a transcription factor, SP-1
Harada et al., Biochem Biophys Res Commun 1990 : Effect of tumor necrosis factor/cachectin on the activity of the low density lipoprotein receptor on human skin fibroblasts
Stopeck et al., J Biol Chem 1993 : Pretreatment with cycloheximide prevented induction of LDL receptor mRNA by TNF, but not by IL-1, suggesting stimulation of LDL receptor transcription by TNF requires protein synthesis
Liao et al., Hepatology 1993 (Carcinoma, Hepatocellular...) : In this study, the effect of tumor necrosis factor on low-density lipoprotein receptor activity was investigated in cells of HepG2, a well differentiated human hepatoma cell line
Kumar et al., J Biol Chem 1998 : Differential roles of extracellular signal regulated kinase-1/2 and p38 ( MAPK ) in interleukin-1beta- and tumor necrosis factor-alpha induced low density lipoprotein receptor expression in HepG2 cells ... Northern analysis demonstrated that IL-1beta or TNF significantly increased LDL receptor transcript in HepG2 cells, whereas expression of another tightly regulated sterol-responsive squalene synthase gene was unaffected ... Similarly, TNF induced LDL receptor expression also required ERK-1/2 activation ... These results show that IL-1beta- or TNF induced LDL receptor expression requires ERK-1/2 activation, that the p38 ( MAPK ) pathway negatively regulates LDL receptor expression, and that sterols inhibit induction at a point downstream of ERK-1/2 in HepG2 cells
Ruan et al., Nephrol Dial Transplant 1998 : TNF alpha , TGF beta, PDGF or IL-1beta did not significantly stimulate HMCL proliferation at the concentrations given above, but maximally stimulated LDLr mRNA expression and increased LDLr promoter activity by 167.48+/-23.56 %, 150.47+/-24.41 %, 127.71+/-24.65 % and 163.01+/-31.91 % respectively, at 24 h ... TNF alpha , TGF beta, PDGF and IL-1beta increased LDLr gene expression by increasing sterol independent and mitogenesis independent gene transcription
Fraunberger et al., Shock 1998 (Shock, Septic) : Recombinant soluble TNF receptors inhibited the TNF induced stimulation of low-density lipoprotein receptor in a concentration dependent manner