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CHUK — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fujioka et al., J Biol Chem 2004
:
Importantly, lack of RelA,
IKK , and p53 as well as expression of a dominant negative IkappaBalpha ( IkappaBalphaM )
inhibited NF-kappaB dependent
p53 activation and apoptosis
Gu et al., J Biol Chem 2004
:
Furthermore, ETS-1 mediated activation of
IKKalpha is negatively
regulated by
p53 binding to ETS-1 ... Induction or enforced overexpression of
p53 represses IKKalpha mRNA and protein expression as well as
IKKalpha promoter activity
Furuya et al., J Biol Chem 2007
:
Here, we show for the first time that p73, but not
p53 , is
stabilized by physical interaction with nuclear
IkappaB kinase (IKK)-alpha to enhance cisplatin ( CDDP ) -induced apoptosis
Yamaguchi et al., J Biol Chem 2007
:
Importantly, the ectopic expression of
IKKalpha into cells silenced for USP11
restores p53 expression, demonstrating that USP11 functions as an upstream regulator of an IKKalpha-p53 signaling pathway
Rasmussen et al., Inflamm Res 2008
(Inflammation) :
An
IkappaB kinase 2 inhibitor, sc514, also strongly reduced IL-8 and significantly
induced p53 protein levels
Jia et al., Cell Death Differ 2013
:
IKK-ß and p85 S6K1
contributed to H ( 2 ) O ( 2 ) -induced phosphorylation of Mdm2 ( S166 ) and
p53 accumulation