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Nagase et al., J Leukoc Biol 2002
:
IFN-alpha, granulocyte-macrophage colony stimulating factor ( GM-CSF ), and G-CSF also inhibited spontaneous CXCR4 expression
Petit et al., Nat Immunol 2002
(Lymphoma) :
We report here that G-CSF induced a reduction of the chemokine stromal cell derived factor 1 (SDF-1) and an increase in its receptor CXCR4 in the bone marrow ( BM ), whereas their protein expression in the blood was less affected
Kim et al., Blood 2006
:
Since bone marrow myeloid cells express G-CSF receptors and G-CSF rapidly reduces CXCR4 expression in purified Gr1 ( + ) cells populations, these results provide evidence that G-CSF acts directly on myeloid lineage cells to reduce CXCR4 expression
Cheng et al., Cardiovasc Drugs Ther 2008
(Myocardial Infarction) :
Flow cytometry revealed that G-CSF slightly increased surface CXCR4 expression on MSCs in vitro
Sato et al., Experimental and clinical cardiology 2012
:
G-CSF had no effect on myocardial stromal derived factor-1 alpha and chemokine (C-X-C motif) receptor 4 ( CXCR4 ) expression in mononuclear cells in the peripheral blood and CXCR4 ( + ) cells in the heart