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IL12B — IL23R
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL23-mediated signaling events:
STAT3 (STAT3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002, Cho et al., J Immunol 2006
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, activates)
Parham et al., J Immunol 2002, Cho et al., J Immunol 2006
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
STAT1 (STAT1)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002
Evidence: physical interaction
-
NCI Pathway Database IL23-mediated signaling events:
SOCS3 (SOCS3)
→
IL23/IL23R/JAK2/TYK2/SOCS3 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2-SOCS3)
(modification, collaborate)
Chen et al., Proc Natl Acad Sci U S A 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
SOCS3 (SOCS3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Chen et al., Proc Natl Acad Sci U S A 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL23/IL23R/JAK2/TYK2/SOCS3 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2-SOCS3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Chen et al., Proc Natl Acad Sci U S A 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL2 (IL2)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(transcription, activates)
Parham et al., J Immunol 2002
-
NCI Pathway Database IL23-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(transcription, activates)
Parham et al., J Immunol 2002
-
NCI Pathway Database IL23-mediated signaling events:
STAT4 (STAT4)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database IL23-mediated signaling events:
STAT3 (STAT3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database IL23-mediated signaling events:
STAT4 (STAT4)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002
Evidence: physical interaction
-
NCI Pathway Database IL23-mediated signaling events:
IL23 complex (IL23A-IL12B)
→
IL23R/JAK2 complex (IL23R-JAK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
Evidence: physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL23 complex (IL23A-IL12B)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
Evidence: physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
Evidence: physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL23R/JAK2 complex (IL23R-JAK2)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
Evidence: physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
IFN-gamma (IFNG)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(transcription, inhibits)
Langrish et al., J Exp Med 2005, Harrington et al., Nat Immunol 2005
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
STAT5A (STAT5A)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002
Evidence: physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Morishima et al., Biochem Biophys Res Commun 2009
:
TGF-beta is necessary for
induction of
IL-23R and Th17 differentiation by IL-6 and
IL-23 ... Here, we found that IL-6 up-regulated
IL-23R mRNA expression, and IL-6 and
IL-23 synergistically
augmented its protein expression ... However, unexpectedly, the up-regulation of
IL-23R and
induction of Th17 differentiation by IL-6 and
IL-23 were almost completely inhibited by anti-TGF-beta ... These results suggest that the
induction of
IL-23R and Th17 differentiation by IL-6 and
IL-23 is mediated through endogenously produced TGF-beta
Staschke et al., J Immunol 2009
(Encephalomyelitis, Autoimmune, Experimental) :
Furthermore, the absence of IRAK4 kinase activity blocked induction of
IL-23R expression, STAT3
activation by
IL-23 , and Th17 cytokine expression in differentiated Th17 cells
Sieve et al., Eur J Immunol 2010
(Listeriosis) :
Mechanistically, the
IL-23 receptor was not required for this phenomenon, and
IL-23 inhibited signaling through the IL-12 receptor by reducing IL-12 induced signal transducer and activator of transcription 4 ( STAT4 ) phosphorylation
Doisne et al., J Immunol 2011
:
In this study, we show that the concomitant presence of IL-1 and IL-23 is crucial to induce a rapid and sustained IL-17A/F and IL-22 response by these cells that requires TCR-CD1d interaction and partly relies on
IL-23 mediated upregulation of
IL-23R and IL-1R1 expression
Sherlock et al., Nat Med 2012
(Arthritis, Experimental...) :
We show here that
IL-23 is essential in enthesitis and
acts on previously unidentified
IL-23 receptor (IL-23R) ( + ), RAR related orphan receptor ?t ( ROR-?t ) ( + ) CD3 ( + ) CD4 ( - ) CD8 ( - ), stem cell antigen 1 (Sca1) ( + ) entheseal resident T cells
Guo et al., PloS one 2012
:
We provide evidence that
IL23R-CHR can bind to IL-23 in a dose dependent manner in vitro, and
block IL-23 signal by IL23R-CHR reducing the ROR?t expression, which in turn lowers the expression of IL-17/IL-22, thus protecting naive CD4+ T cells against Th17 development
Shen et al., PloS one 2013
:
Variable expression of CD161,
IL-23R and RORC
affects IL-23 responsiveness and contributes to the inter-individual susceptibility to IL-23 mediated defenses and inflammatory processes