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CHUK — IRF3

Text-mined interactions from Literome

Perry et al., J Exp Med 2004 (Virus Diseases) : TANK binding kinase-1 (TBK1) and the inducible IkappaB kinase ( IKK-i ) have been shown recently to activate interferon (IFN) regulatory factor-3 ( IRF3 ), the primary transcription factor regulating induction of type I IFNs
DiPerna et al., J Biol Chem 2004 : Poxvirus protein N1L targets the I-kappaB kinase complex , inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors
Wang et al., Mol Immunol 2008 : Differential regulation of IKK alpha mediated activation of IRF3/7 by NIK ... However, mutation of the two serine residues has differential effects on IKK alpha mediated activation of IRF3/7 ... While IKK alpha ( S176E ) constitutively activates IRF3/7 , IKK alpha ( S180E ) losses its ability to activate IRF3/7 ... These findings suggest that IKK alpha mediated activation of NF-kappaB and IRF3/7 are differentially regulated by NIK, and NIK plays an important role in TLR7/9 mediated IFN-alpha production
Liang et al., Cell Res 2011 (Sarcoma, Kaposi) : Importantly, expression of miR-K12-11 attenuated IFN signaling by decreasing IKK? mediated IRF3/IRF7 phosphorylation and by inhibiting the activation of IKK? dependent IFN stimulating genes ( ISGs ), allowing miR-K12-11 suppression of antiviral immunity