Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
BCL2
→
MIR16-1
(directlyDecreases)
Mott et al., Oncogene 2007* Evidence: Whereas relatively few microRNA targets have been experimentally described, significantly, the prototypical anti-apoptotic protein Bcl-2 is a target of microRNA regulation. mir-15 and mir-16 have base complementarity (including the seed region) to the Bcl-2 mRNA, and overexpression of mir-15/16 leads to decreased Bcl-2 protein and increased cell death (Cimmino et al., 2005).