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BCL2 — BID

Pathways - manually collected, often from reviews:

• Reactome Reaction: BCL2 → BID (reaction) Puthalakath et al., Mol Cell 1999, Oda et al., Science 2000*, Nakano et al., Mol Cell 2001, Puthalakath et al., Science 2001, Yi et al., J Biol Chem 2003, Yang et al., Cell 1995*
• Reactome Reaction: BCL2 → BID (direct_complex) Puthalakath et al., Mol Cell 1999, Oda et al., Science 2000*, Nakano et al., Mol Cell 2001, Puthalakath et al., Science 2001, Yi et al., J Biol Chem 2003, Yang et al., Cell 1995*
• WikiPathways TP53 Network: TNFSF10 → Complex of BID-BCL2 (inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: BID — BCL2 (two hybrid) Cartron et al., Mol Cell 2004*
• IRef Bind_translation Interaction: BID — BCL2 (competition binding) Chen et al., Mol Cell 2005
• IRef Biogrid Interaction: BID — BCL2 (direct interaction, unspecified method) Chen et al., Mol Cell 2005
• IRef Biogrid Interaction: BID — BCL2 (direct interaction, unspecified method) Real et al., Cancer Res 2004*
• IRef Corum Interaction: BID — BCL2 (association, cross-linking study) Cheng et al., Mol Cell 2001*
• IRef Corum Interaction: BID — BCL2 (association, coimmunoprecipitation) Cheng et al., Mol Cell 2001*
• IRef Dip Interaction: BID — BCL2 (physical association, anti bait coimmunoprecipitation) Chipuk et al., Proc Natl Acad Sci U S A 2008*
• IRef Hprd Interaction: Complex of BCL2-BID-BAX-BAX-BID-BCL2-BID-BCL2-BAX (in vivo) Yi et al., J Biol Chem 2003
• IRef Hprd Interaction: Complex of BCL2-BID-LMNB1-LMNB1-BCL2-BID-LMNB1-BID-BCL2 (in vivo) Yi et al., J Biol Chem 2003
• IRef Hprd Interaction: BID — BCL2 (in vivo) Cheng et al., Mol Cell 2001*, Yi et al., J Biol Chem 2003, Certo et al., Cancer Cell 2006, Huang et al., EMBO J 1998*, Luo et al., Cell 1998*
• IRef Hprd Interaction: BID — BCL2 (in vitro) Cheng et al., Mol Cell 2001*, Yi et al., J Biol Chem 2003, Certo et al., Cancer Cell 2006, Huang et al., EMBO J 1998*, Luo et al., Cell 1998*
• IRef Intact Interaction: Complex of BCL2L1-BCL2-BCL2L2-BCL2L2-PABPN1-BAX-BID (association, anti tag coimmunoprecipitation) Willis et al., Science 2007
• IRef Intact Interaction: Complex of BID-BAX-BID-BCL2-BAX-BAX-BCL2-BCL2-BID (association, anti tag coimmunoprecipitation) Willis et al., Science 2007
• IRef Intact Interaction: BID — BCL2 (physical association, anti tag coimmunoprecipitation) Willis et al., Science 2007
• IRef Intact Interaction: BID — BCL2 (direct interaction, fluorescence polarization spectroscopy) Certo et al., Cancer Cell 2006
• IRef Intact Interaction: BID — BCL2 (physical association, anti bait coimmunoprecipitation) Huang et al., EMBO J 1998*
• IRef Intact Interaction: BID — BCL2 (physical association, coimmunoprecipitation) Yi et al., J Biol Chem 2003
• IRef Intact Interaction: BID — BCL2 (direct interaction, inferred by curator) Hermjakob et al., Nucleic Acids Res 2004
• IRef Ophid Interaction: BID — BCL2 (aggregation, confirmational text mining) Luo et al., Cell 1998*
• IRef Ophid Interaction: BID — BCL2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Bortul et al., Leukemia 2003 : We did not observe a protective effect of Bcl-X ( L ) or Bcl-2 against the cytotoxic activity of TRAIL, even though TRAIL induced cleavage of BID
Gallicchio et al., Br J Pharmacol 2008 (Colonic Neoplasms) : Celecoxib showed a pro-apoptotic effect, inducing Bax and BID but down regulating Bcl-2
Campbell et al., J Urol 2008 (Ureteral Obstruction) : Renal obstruction induced increased tumor necrosis factor-alpha production, apoptotic renal tubular death, the expression of Bax, caspase 8 and truncated BID , and mitochondrial release of cytochrome C, while simultaneously stimulating decreased Bcl-2 and Bcl-x ( L ) expression