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HGF — SPP1

Text-mined interactions from Literome

Grano et al., J Biol Regul Homeost Agents 2002 : Moreover HGF and M-CSF induce de novo synthesis of OPN ... In conclusion, these data suggest that HGF and M-CSF stimulate OPN production by MDA-231 cells, and that OPN is subsequently used as a substrate for cell adhesion
Ariztia et al., Exp Cell Res 2003 (Neoplasm Metastasis...) : Autocrine secretion of HGF resulted in sustained expression of OPN
Chen et al., PloS one 2012 : Hepatocyte growth factor increases osteopontin expression in human osteoblasts through PI3K, Akt, c-Src, and AP-1 signaling pathway ... However, the effects of HGF on OPN expression in human osteoblasts are large unknown ... Here we found that HGF induced OPN expression in human osteoblasts dose-dependently ... HGF mediated OPN production was attenuated by c-Met inhibitor and siRNA ... Our results suggest that the interaction between HGF and c-Met increases OPN expression in human osteoblasts via the PI3K, Akt, c-Src, c-Jun, and AP-1 signaling pathway