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RHOA — SPP1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Osteopontin-mediated events: Rho family GTPase (RAC1/RHOA/CDC42) → alphav/beta3 Integrin/Osteopontin complex (SPP1-ITGAV-ITGB3) (modification, collaborate)
  Chellaiah et al., J Biol Chem 2000, Chellaiah et al., J Biol Chem 2003

Text-mined interactions from Literome

Meacci et al., FEBS Lett 2000 : Notably, treatment with Gö6976, an inhibitor of conventional PKCs, which selectively blocked PKC alpha in these cells, prevented SPP induced Rho A translocation
Teramoto et al., Oncogene 2003 : For example, H-Ras V12 upregulated osteopontin and Akt 1, and H-Ras and RhoA stimulated cyclin G1, cyclin dependent kinase 8, cyclin A2 and HMGI-C, while Rac1 QL and Cdc42 QL upregulated extracellular matrix and cell adhesion proteins such as alpha-actinin 4, procollagen type I and V and neuropilin
Hong et al., Mol Cell Biochem 2010 : Activation of RhoA and FAK induces ERK mediated osteopontin expression in mechanical force subjected periodontal ligament fibroblasts