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NOTCH1 — STAT3
Text-mined interactions from Literome
Kamakura et al., Nat Cell Biol 2004
:
Here we show that
STAT3 is activated in the
presence of active
Notch , as well as the Notch effectors Hes1 and Hes5
Covey et al., Neuroscience 2007
(Hypoxia-Ischemia, Brain) :
Modeling the changes that occur in vivo, we show that LIF
induces Stat-3 phosphorylation in neurospheres to enhance Delta-like-1 and Notch1 expression as well as to increase
Notch1 activation
Gouti et al., Stem Cells 2008
:
This was partially attributed to Hoxb1 dependent activation of the Notch signaling pathway and
Notch dependent
STAT3 phosphorylation at Ser 727, thus linking Hox gene function with maintenance of active Notch signaling and the JAK/STAT pathway
Lee et al., Mol Cancer Res 2009
:
SRC kinase was found to be responsible for the enhanced
STAT3 phosphorylation in
response to
Notch signaling
Bhoopathi et al., Cancer Res 2011
(Brain Neoplasms...) :
Taken together, our results suggest that SPARC induces expression of neuronal markers in medulloblastoma cells through its inhibitory effect on IL-6 regulated suppression of
Notch pathway
mediated STAT3 signaling, thus giving further support to the potential use of SPARC as a therapeutic candidate for medulloblastoma treatment
Tsuyada et al., Cancer Res 2012
(Breast Neoplasms) :
Increased CCL2 expression in activated fibroblasts required
STAT3 activation by diverse breast cancer secreted cytokines, and in turn,
induced NOTCH1 expression and the CSC features in breast cancer cells, constituting a cancer-stroma-cancer signaling circuit