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INSR — SHC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SHC1 → INSR (directlyIncreases, SHC1 Activity)
  Evidence: Phosphotyrosine at site 960 of the b subunit just inside the membrane creates an NPXpY-recognition motif for the PTB domain of the IRS proteins. Modification of this tyrosine completely inhibits subsequent phosphorylation of IRS-1 and other insulin receptor substrates and leads to loss of most insulin-dependent biological actions
• OpenBEL Selventa BEL large corpus: SHC1 → INSR (directlyIncreases, SHC1 Activity)
  Evidence: Insulin receptor substrates are a growing family of proteins that are phosphorylated by the activated insulin receptor. To date, nine members of this family have been identified, including IRS-1 (17, 18), IRS-2 (19), IRS-3 (20), and IRS-4 (21), which are generally viewed as the most specific for insulin signaling; Gab-1 (22); Shc, which has three isoforms (23); and p62dok Following insulin binding, the receptor undergoes autophosphorylation on multiple tyrosine residues. This results in activati...
• OpenBEL Selventa BEL large corpus: SHC1 → INSR (directlyIncreases, SHC1 Activity)
  Evidence: insulin stimulates the mitogen-activated protein (MAP) kinase extracellular signalregulated kinase (ERK) (Fig. 2). This pathway involves the tyrosine phosphorylation of IRS proteins and/or Shc, which in turn interact with the adapter protein Grb2, recruiting the Son-of-sevenless (SOS) exchange protein to the plasma membrane for activation of Ras.
• OpenBEL Selventa BEL large corpus: SHC1 → INSR (directlyIncreases, SHC1 Activity)
  Evidence: insulin receptor is a tyrosine kinase that catalyzes the phosphorylation of several intracellular substrates, including the insulin receptor substrate (IRS) proteins, GAB-1, Shc, APS, p60(DOK), SIRPS, and c-Cbl
• OpenBEL Selventa BEL large corpus: SHC1 → INSR (directlyIncreases, SHC1 Activity)
  Evidence: insulin receptor phosphorylates a number of intracellular substrates on tyrosine including members of the insulin receptor substrate family (IRS1/2/3/4), the Shc adaptor...
• OpenBEL Selventa BEL large corpus: SHC1 → INSR (directlyIncreases, SHC1 Activity)
  Evidence: 11075717;9710204;8610109;9741627;12522270;15592455;9927207
• BioCarta insulin signaling pathway: Insulin/Insulin/Insulin Ra/Insulin Ra/Insulin Rb/Insulin Rb complex (INSR-INS) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• KEGG Insulin signaling pathway: INSR → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) → SHC (SHC1) (modification, collaborate) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) → GRB2 (GRB2) (modification, collaborate) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) → Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) (modification, collaborate)
  Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) → SHIP (INPP5D) (modification, collaborate) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) → SHC/SHIP complex (SHC1-INPP5D) (modification, collaborate)
  Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: SHC (SHC1) → Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) (modification, collaborate)
  Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) → SHC/SHIP complex (SHC1-INPP5D) (modification, collaborate)
  Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → None (modification, activates) Mahadev et al., J Biol Chem 2001
  Evidence: assay
• NCI Pathway Database Insulin Pathway: GRB2 (GRB2) → Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1) (modification, collaborate)
  
• NCI Pathway Database Insulin Pathway: GRB2 (GRB2) → Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) (modification, collaborate)
  
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1) → SOS1 (SOS1) (modification, collaborate)
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1) → Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) (modification, collaborate)
  
• NCI Pathway Database Insulin Pathway: SOS1 (SOS1) → Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) (modification, collaborate)
  
• NCI Pathway Database Insulin Pathway: IRS1 (IRS1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) (modification, collaborate)
  Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
• NCI Pathway Database Insulin Pathway: SHC (SHC1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) (modification, collaborate)
  Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
• NCI Pathway Database Insulin Pathway: SHC (SHC1) → Insulin Receptor/Insulin complex (INSR-INS) (modification, collaborate)
  Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
• NCI Pathway Database Insulin Pathway: GRB2 (GRB2) → Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) (modification, collaborate)
  Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
• NCI Pathway Database Insulin Pathway: PTP1B (PTPN1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) (modification, collaborate)
  Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) → Insulin Receptor/Insulin complex (INSR-INS) (modification, collaborate)
  Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) (modification, collaborate)
  Ozes et al., Proc Natl Acad Sci U S A 2001, Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → IRS1 (IRS1) (modification, collaborate) Ozes et al., Proc Natl Acad Sci U S A 2001, Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → Insulin Receptor/Insulin complex (INSR-INS) (modification, collaborate)
  Ozes et al., Proc Natl Acad Sci U S A 2001, Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → SHC (SHC1) (modification, collaborate) Ozes et al., Proc Natl Acad Sci U S A 2001, Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) → SHC (SHC1) (modification, collaborate) Ozes et al., Proc Natl Acad Sci U S A 2001, Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin complex (INSR-INS) → SHC (SHC1) (modification, collaborate) Ozes et al., Proc Natl Acad Sci U S A 2001, Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Signaling events mediated by PTP1B: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) (modification, collaborate)
  Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Signaling events mediated by PTP1B: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → IRS1 (IRS1) (modification, collaborate) Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Signaling events mediated by PTP1B: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → Insulin Receptor/Insulin complex (INSR-INS) (modification, collaborate)
  Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Signaling events mediated by PTP1B: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → SHC (SHC1) (modification, collaborate) Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Signaling events mediated by PTP1B: Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1) → SHC (SHC1) (modification, collaborate) Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Signaling events mediated by PTP1B: Insulin Receptor/Insulin complex (INSR-INS) → SHC (SHC1) (modification, collaborate) Yamauchi et al., J Biol Chem 1994, Isakoff et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1) → HRAS/GTP complex (HRAS) (modification, activates) Wick et al., J Biol Chem 2001, Ouwens et al., J Biol Chem 1994, Yamauchi et al., J Biol Chem 1994, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1) → HRAS/GDP complex (HRAS) (modification, activates) Wick et al., J Biol Chem 2001, Ouwens et al., J Biol Chem 1994, Yamauchi et al., J Biol Chem 1994, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Insulin Pathway: GRB10 (GRB10) → Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) (modification, collaborate)
  O'Neill et al., J Biol Chem 1996, Dong et al., Mol Endocrinol 1997*
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: GRB10 (GRB10) → Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10) (modification, collaborate)
  O'Neill et al., J Biol Chem 1996, Dong et al., Mol Endocrinol 1997*
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1) → Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10) (modification, collaborate)
  O'Neill et al., J Biol Chem 1996, Dong et al., Mol Endocrinol 1997*
  Evidence: physical interaction
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → SOS1 (SOS1) (modification, collaborate) Pronk et al., Mol Cell Biol 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) (modification, collaborate)
  Pronk et al., Mol Cell Biol 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Insulin Pathway: SOS1 (SOS1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) (modification, collaborate)
  Pronk et al., Mol Cell Biol 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10) → p62DOK (DOK1) (modification, inhibits) Wick et al., J Biol Chem 2001
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10) → Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1) (modification, inhibits)
  Wick et al., J Biol Chem 2001
  Evidence: assay
• NCI Pathway Database Insulin Pathway: PTP1B (PTPN1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) (modification, collaborate)
  Goldstein et al., J Biol Chem 2000, Dadke et al., J Biol Chem 2000, Seely et al., Diabetes 1996, Bandyopadhyay et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database Insulin Pathway: PTP1B (PTPN1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) (modification, collaborate)
  Goldstein et al., J Biol Chem 2000, Dadke et al., J Biol Chem 2000, Seely et al., Diabetes 1996, Bandyopadhyay et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1) → Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1) (modification, collaborate)
  Goldstein et al., J Biol Chem 2000, Dadke et al., J Biol Chem 2000, Seely et al., Diabetes 1996, Bandyopadhyay et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → HRAS/GTP complex (HRAS) (modification, activates) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → SHC/SHIP complex (SHC1-INPP5D) (modification, activates)
  Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database Insulin Pathway: Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1) → HRAS/GDP complex (HRAS) (modification, activates) Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
  Evidence: assay
• Reactome Reaction: INSR → SHC1 (reaction)
• Reactome Reaction: INSR → SHC1 (indirect_complex)
• WikiPathways Angiopoietin Like Protein 8 Regulatory Pathway: INSR → SHC2/SHC3/SHC1 (activation)
• WikiPathways Insulin Signaling: INSR → SHC3/IRS1/IRS2/SHC1/IRS4/SHC2/GAB1 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: SHC1 — INSR van der Geer et al., Oncogene 1999*
• IRef Bind_translation Interaction: SHC1 — INSR (coimmunoprecipitation) van der Geer et al., Oncogene 1999*
• IRef Biogrid Interaction: SHC1 — INSR (direct interaction, two hybrid) Kasus-Jacobi et al., Oncogene 2000*
• IRef Hprd Interaction: SHC1 — INSR (in vitro) Marchetto et al., Leukemia 1999*, Nakajima et al., J Biol Chem 2000*, Slack et al., Biochem J 2000*, Schaak et al., Gut 2000*, Imokawa et al., J Biol Chem 2000*, Sasaoka et al., Endocr J 2000*, Roccato et al., Br J Cancer 2002*, Sasaoka et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997, Gotoh et al., Mol Cell Biol 1997*, Soltoff et al., J Biol Chem 1998*, Walk et al., Eur J Immunol 1998, Wary et al., Cell 1998*
• IRef Hprd Interaction: SHC1 — INSR (in vivo) Marchetto et al., Leukemia 1999*, Nakajima et al., J Biol Chem 2000*, Slack et al., Biochem J 2000*, Schaak et al., Gut 2000*, Imokawa et al., J Biol Chem 2000*, Sasaoka et al., Endocr J 2000*, Roccato et al., Br J Cancer 2002*, Sasaoka et al., J Biol Chem 1996*, Ishihara et al., J Biol Chem 1997, Gotoh et al., Mol Cell Biol 1997*, Soltoff et al., J Biol Chem 1998*, Walk et al., Eur J Immunol 1998, Wary et al., Cell 1998*
• IRef Intact Interaction: SHC1 — INSR (physical association, two hybrid) Klammt et al., Biochem Biophys Res Commun 2005*
• IRef Intact Interaction: SHC1 — INSR (physical association, pull down) Kayali et al., J Biol Chem 1998*
• IRef Ophid Interaction: SHC1 — INSR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Rocha et al., Curr Eye Res 2000 (Diabetes Mellitus, Experimental) : The activation of insulin receptors following insulin treatment, and the involvement of insulin receptor substrates-1 and -2, Shc , JAK-2 and STAT-1, were analyzed by immunoprecipitation, followed by SDS-PAGE and immunoblotting of rat lacrimal and salivary glands after exposure to insulin
Myers et al., Mol Cell Biol 1994 : Coexpression of IRS-1 or IRS-1F-895 with the insulin receptor was required for insulin stimulated mitogenesis in 32-D cells, while expression of the insulin receptor alone was sufficient to mediate insulin stimulated tyrosine phosphorylation of Shc and activation of p21ras and mitogen activated protein ( MAP ) kinase
Skolnik et al., Science 1993 : In contrast to the activated epidermal growth factor receptor that binds the GRB2-Sos complex directly, activation of the insulin receptor results in the interaction of GRB2-Sos with IRS-1 and Shc , thus linking the insulin receptor to Ras signaling pathways
Gliozzo et al., J Cell Biochem 1998 (Breast Neoplasms) : In these cells, both Shc tyrosine phosphorylation and mitogen activated protein kinase ( MAP-K ) activity were increased by the insulin receptor ( indicating that the p21ras pathway may account for insulin stimulated cell growth in ZR-75-1 cells )