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IL1A — TAB2
Text-mined interactions from Literome
Takaesu et al., Mol Cell 2000
:
Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant negative mutant
TAB2 impairs their activation by
IL-1 ...
IL-1 stimulates translocation of
TAB2 from the membrane to the cytosol where it mediates the IL-1 dependent association of TAK1 with TRAF6
Takaesu et al., Mol Cell Biol 2001
(MAP Kinase Signaling System) :
We show that
IL-1 stimulation
induces the rapid but transient association of IRAK, TRAF6,
TAB2 , and TAK1 ... We show that
IL-1 stimulation
induces the rapid but transient association of IRAK, TRAF6,
TAB2 , and TAK1
Qian et al., J Biol Chem 2001
:
The membrane bound IRAK similarly mediates the
IL-1 induced translocation of
TAB2 from the membrane to the cytosol ... Our results show that IRAK is required for the
IL-1 induced phosphorylation of TAK1,
TAB1 , and TAB2