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IL1A — VEGFA

Text-mined interactions from Literome

Norrby et al., APMIS 1998 : These data suggest that nitric oxide can act as an endogenous suppressor of mammalian de novo angiogenesis, which is a new finding, and, moreover, that angiogenesis induced by VEGF165 on the one hand and by bFGF and IL-1 on the other in the rat mesenteric window depends on different pathways
Ko et al., Mol Cell Probes 1999 : We could demonstrate in HUAEC that stimulation with IL-1alpha- and TNF-alpha led to the mRNA expression of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor ( VEGF ) which are crucial in the process of angioneogenesis and atherosclerosis as well as of the granulocyte-colony stimulating factor ( G-CSF ), granulocyte macrophage-colony stimulating factor ( GM-CSF ) and stem cell factor (SCF) which are main growth factors in haematopoiesis
Valter et al., Int J Dev Neurosci 1999 (Glioma...) : IL-1 caused a fast and strong increase of VEGF secretion in U-87 MG which appeared to harbor an intracellular VEGF pool for enhanced exocytosis ... This suggests that baseline secretion of VEGF involves IL-1 receptor activation by endogenously produced IL-1 ... In general, the effects of IL-1 and EGF on VEGF were additive, suggesting independent mechanisms
Levitas et al., J Soc Gynecol Investig 2000 : Thus, IL-1 mediated VEGF induction may constitute one of several end points through which IL-1 may coordinate and perhaps amplify the ovulatory cascade
Cho et al., J Immunol 2000 (Arthritis, Rheumatoid) : Stimulation of FLS with TNF-alpha, IL-1beta , and TGF-beta increased VEGF production by 1.6-, 2.0-, and 5.2-fold, respectively, and displayed an additive effect on the production of VEGF by CD40L
Tsuji et al., Biol Pharm Bull 2000 : We investigated the effects of various sulfhydryl compounds on interleukin-1 (IL-1) induced vascular endothelial growth factor ( VEGF ) production in human synovial stromal cells ( HSSC ) ... These results suggest that bucillamine may be a selective inhibitor of IL-1 induced VEGF production in HSSC, and that inhibition of VEGF production may require not only SH groups but also a specific chemical structure
Imaizumi et al., Thromb Haemost 2000 : Cycloheximide treatment of HUVEC slightly inhibited the IL-1alpha induced expression of VEGF mRNA, and IL-1alpha may mediate , at least in part, VEGF expression in response to IL-1alpha
Salven et al., FASEB J 2002 : We show that IL-1alpha stimulates VEGF secretion by human peripheral blood mononuclear cells ( PBMNCs ) in a dose dependent manner
Koyama et al., Eur Respir J 2002 : Interleukin (IL)-1beta and tumour necrosis factor (TNF)-alpha augmented the release of VEGF in a time- and dose dependent manner
Qian et al., Biol Reprod 2004 (MAP Kinase Signaling System) : Meanwhile, IL-1 beta also induced the secretion of VEGF in normal human cytotrophoblast cells ... These data indicate that, in normal human cytotrophoblast cells, IL-1 beta induces HIF- 1 alpha mediated VEGF secretion and that IL-1 beta stimulated ERK1/2 activation may be involved in this process
Honorati et al., Osteoarthritis Cartilage 2004 (Arthritis, Rheumatoid...) : IL-17, IL-1beta and TNF-alpha stimulate VEGF production by dedifferentiated chondrocytes
Chu et al., J Endod 2004 (Neovascularization, Pathologic) : Both IL-1alpha and TNF-alpha induced significantly high levels of VEGF mRNA gene expression in human pulp and gingival fibroblasts ( p < 0.05 )
Inoue et al., Rheumatol Int 2005 (Osteoarthritis, Hip...) : We investigated the effects of interleukin (IL)-1 on vascular endothelial growth factor ( VEGF ) and matrix metalloproteinase-3 (MMP-3) ( stromelysin ) secretion from chondrocytes and synoviocytes in different clinical conditions ... Interleukin-1ra significantly suppressed the enhancing effect of IL-1 on MMP-3 and VEGF in both cell types ... In conclusion, IL-1 simultaneously induces MMP-3 and VEGF production from chondrocytes and synoviocytes in inflammatory, degenerative, and post-traumatic joints
Stocks et al., FEBS Lett 2005 : In conclusion, IL-1beta increases VEGF-A secretion by COX-2 derived PGE ( 2 ) production whereas TGFbeta uses COX independent pathways
Murata et al., J Orthop Res 2006 (Anoxia...) : Distinct signaling pathways are involved in hypoxia- and IL-1 induced VEGF expression in human articular chondrocytes ... In contrast, IL-1 induced VEGF secretion was blocked by JNK inhibitor, and not by p38MAPK inhibitor ... We demonstrate that hypoxia and IL-1 induce VEGF production in chondrocytes through distinct MAPK signaling pathways, indicating that VEGF is induced in a HIF-1 dependent or -independent manner in chondrocytes
Kalinski et al., Hum Pathol 2007 (Bone Neoplasms...) : We further used a chondrosarcoma cell line to study the effect of interleukin (IL)-1beta and hypoxia on the regulation of ADAMTS1 and VEGF-A expression
Boivin et al., Exp Dermatol 2006 : The stimulatory effect of IL-1alpha on DPC VEGF , GM-CSF, KGF, and IL-8 expression was also evident at the mRNA level for these cytokines
Nasu et al., Gynecol Endocrinol 2006 : The aim of the present study was to evaluate the effects of interleukin (IL)-1beta on the production of vascular endothelial growth factor ( VEGF ) and soluble fms-like tyrosine kinase-1 ( sFlt-1 ) in the human fallopian tube
Rega et al., Arterioscler Thromb Vasc Biol 2007 : Furthermore, IL-1beta synergistically enhanced the effect of OSM on VEGF production
Tsuji et al., Int Immunopharmacol 2007 : We investigated the bucillamine ( Buc ) mechanism inhibiting interleukin (IL)-1beta induced vascular endothelial growth factor ( VEGF ) production from human fibroblast-like synoviocytes ( HFLS ) which derived from the inflamed synovium of an RA patient using SA981, its active metabolite
Kommineni et al., Biochem Biophys Res Commun 2008 (Corneal Neovascularization) : TNF-alpha and IL-1 induced VEGF-A secretion by corneal fibroblasts ( HCRF ) and this was inhibited significantly by IFN-gamma
Bando et al., J Periodontal Res 2009 : In the present study, we investigated whether interleukin-1alpha induced vascular endothelial growth factor production in human periodontal ligament cells and whether cyclooxygenase-2 derived prostaglandin E ( 2 ) regulated interleukin-1alpha induced vascular endothelial growth factor production ... Interleukin-1alpha induced vascular endothelial growth factor production in a dose dependent and time dependent manner ... Exogenous prostaglandin E ( 2 ), butaprost ( an EP2 receptor agonist ) and dibutyryl cAMP abolished the inhibitory effect of indomethacin on interleukin-1alpha induced vascular endothelial growth factor production ... We suggest that interleukin-1alpha induced vascular endothelial growth factor production via cyclooxygenase-2 derived prostaglandin E ( 2 ) in human periodontal ligament cells
Lu et al., Invest Ophthalmol Vis Sci 2009 (Burns, Chemical...) : Moreover, IL-1 alpha and IL-1 beta enhanced VEGF and iNOS expression by murine peritoneal macrophages
Murayama et al., Cell Biol Int 2010 : Effect of VEGF ( vascular endothelial growth factor ) on expression of IL-8 ( interleukin-8 ), IL-1beta and their receptors in bovine theca cells ... Secondly, we examined the effects of VEGF on the expression of IL-8, IL-1beta and their receptors genes in cultured bovine theca cells
Perera et al., Arthritis Res Ther 2010 (Inflammation) : However, IL-1beta did not induce SOX-9, VEGF , and c-Myc gene expression and inhibited AC cell proliferation
Lee et al., J Orthop Res 2011 (Intervertebral Disc Degeneration...) : In this study, we investigated the effects of inflammatory cytokines, IL-1ß , and TNF-a, on the expression of an angiogenic factor, vascular endothelial growth factor ( VEGF ), and neurotrophic factors, nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), in human IVD degeneration ... IL-1ß and TNF-a stimulated the gene expression of VEGF , NGF, and BDNF in nucleus pulposus ( NP ) cells isolated from patient tissues
Zhu et al., Am J Respir Cell Mol Biol 2011 (Asthma) : Troglitazone dose-dependently reduced the IL-1ß induced release of IL-6 and vascular endothelial growth factor , the TNF-a induced release of eotaxin and regulated on activation, normal T expressed and secreted ( RANTES ), and the IL-4 induced release of eotaxin
Grimstad et al., Wound Repair Regen 2011 : New interactions between cytokines and growth factors were revealed, which may have important roles in wound healing, including IL-1ß induced IFN-? and IL-10 induced VEGF
Choe et al., Joint Bone Spine 2012 (Arthritis, Rheumatoid...) : This study aimed to identify the regulatory effect of tacrolimus on the interleukin-1ß (IL-1ß) induced expressions of angiopoietin-1 (Ang-1), Tie-2 receptor ( Tie-2 ), and vascular endothelial growth factor ( VEGF ) in human rheumatoid fibroblast-like synoviocytes ( FLS ) and to determine the regulatory mechanism in the mitogen activated protein kinases ( MAPKs ) signaling pathway ... IL-1ß induced Ang-1, Tie-2, and VEGF expressions with and without tacrolimus were measured in cultured FLS using real time-polymerase chain reaction, enzyme linked immunosorbent assay, Western blotting, and immunofluorescence staining
Moon et al., Spine (Phila Pa 1976) 2012 (Fibrosis...) : Prior macrophage exposure increased the secretion of IL-8 and VEGF in response to TNF-a/IL-1ß stimulation whereas IL-6 production was increased in response to IL-1ß
Guo et al., PloS one 2011 (Mammary Neoplasms, Animal) : Notch, IL-1 and leptin crosstalk outcome ( NILCO ) is critical for leptin induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer
Hoffmann et al., Biochem Pharmacol 2011 (Adenocarcinoma...) : Proinflammatory IL-6 and PGHS-2 as well as proangiogenic IL-8 and VEGF were induced by IL-1 , whereas the secretion of invasion promoting MMP-2 remained unaffected
Agis et al., J Periodontal Res 2012 : This increase of VEGF was observed in the presence of proinflammatory IL-1 and pharmacological inhibitors of JNK and p38 signaling ... These results suggest that PHD inhibitors enhance the production of VEGF in periodontal fibroblasts, even in the presence of proinflammatory IL-1
Clockaerts et al., Ann Rheum Dis 2012 (Osteoarthritis, Knee) : IL-1ß increased gene expression of PTGS2, TNFa, IL-1ß, IL-6 and VEGF and increased TNFa release in IPFP
Hsieh et al., J Comp Neurol 2012 (Neuralgia) : We investigated the effects of low-level laser on the accumulation of HIF-1a, tumor necrosis factor-a (TNF-a), and interleukin-1ß (IL-1ß) in controlling neuropathic pain, as well as on the activation of vascular endothelial growth factor ( VEGF ) and nerve growth factor (NGF) in promoting functional recovery in a rat CCI model
Yang et al., Inflammation 2012 : However, pretreatment with LY294002 significantly diminished IL-1ß induced proliferation, migration, adhesion, and VEGF-A production
Finetti et al., PloS one 2012 (Carcinoma, Squamous Cell...) : AF3485 abolished IL-1ß induced activation of the EGFR, decreasing VEGF and FGF-2 expression, and tumor mediated endothelial tube formation
Kloesch et al., Int Immunopharmacol 2013 (Arthritis, Rheumatoid) : VEGF-A expression could only be detected in RA-FLS and was induced by PMA, but not by IL-1ß
Ben-Av et al., FEBS Lett 1995 (Arthritis, Rheumatoid...) : We demonstrate that PGE2 and IL-1 induces the expression of vascular endothelial growth factor ( VEGF ), a selective angiogenic factor by rheumatoid synovial fibroblast cells ... The induction of VEGF expression by PGE2 and interleukin-1 alpha may be an important mechanism in inflammatory angiogenesis
Berse et al., Clin Exp Immunol 1999 (Anoxia...) : The stimulatory effects of TGF-beta and IL-1 on VEGF secretion were additive