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Huang et al., Biochem Pharmacol 2011
(Carcinoma, Non-Small-Cell Lung) :
Moreover, MTX promoted p53 phosphorylation at Ser15 and acetylaion at Lys373/382, which increase its stability and expression
Spurlock et al., Arthritis Rheum 2012
(Arthritis, Rheumatoid...) :
In tissue culture, MTX induced expression of both p53 and p21 by JNK-2- and JNK-1 dependent mechanisms, respectively, while CHEK2 and RANGAP1 were not induced by MTX