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BRCA2 — TP53

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TP53 → BRCA2 (decreases, BRCA2 Activity, TP53 Activity) Marmorstein et al., Proc Natl Acad Sci U S A 1998*
  Evidence: Modified assertion

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BRCA2 — TP53 (physical association, affinity chromatography technology) Dong et al., Mol Cell 2003
• IRef Biogrid Interaction: BRCA2 — TP53 (association, biochemical) Dong et al., Mol Cell 2003
• IRef Biogrid Interaction: BRCA2 — TP53 (physical association, affinity chromatography technology) Marmorstein et al., Proc Natl Acad Sci U S A 1998*
• IRef Dip Interaction: BRCA2 — TP53 (direct interaction, pull down) Rajagopalan et al., Proc Natl Acad Sci U S A 2010*
• IRef Dip Interaction: BRCA2 — TP53 (direct interaction, coimmunoprecipitation) Marmorstein et al., Proc Natl Acad Sci U S A 1998*
• IRef Dip Interaction: BRCA2 — TP53 (direct interaction, classical fluorescence spectroscopy) Rajagopalan et al., Proc Natl Acad Sci U S A 2010*
• IRef Dip Interaction: BRCA2 — TP53 (direct interaction, nuclear magnetic resonance) Rajagopalan et al., Proc Natl Acad Sci U S A 2010*
• IRef Dip Interaction: BRCA2 — TP53 (direct interaction, isothermal titration calorimetry) Rajagopalan et al., Proc Natl Acad Sci U S A 2010*
• IRef Ophid Interaction: BRCA2 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wang et al., Cancer Res 2001 : Surprisingly, down-regulation of BRCA2 by UV does not require functional p53 , which has been suggested to be required for the down-regulation of BRCA1 and BRCA2 mRNAs by DNA damaging agents
Wu et al., J Biol Chem 2003 : Thus, BRCA2 levels in the cell are regulated by three independent mechanisms in a p53 dependent manner
Tannenbaum et al., International journal of biological sciences 2007 : Increased expression of p53 in the mimicked heterozygous cells was observed, perhaps in response to BRCA2 deficiency
Rajagopalan et al., Proc Natl Acad Sci U S A 2010 : Overexpression of BRCA2 and BRCA2 ( CTD ) suppressed the transcriptional activity of p53 with a concomitant reduction in the expression of p53-target genes such as Bax and p21