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OCLN — TNF
Text-mined interactions from Literome
Wachtel et al., J Neurochem 2001
:
Removal of
TNF from astrocytes
restored the basal level of
occludin
Siu et al., Endocrinology 2003
:
TNFalpha also
inhibited the timely induction of
occludin , which is known to associate with the Sertoli cell TJ-barrier assembly
Cui et al., Zhonghua Nei Ke Za Zhi 2007
(Disease Models, Animal...) :
The reduction of tight junction protein
occludin in intestinal epithelial cells may be a
result of the production of
TNFalpha in mice with fulminant hepatic failure
Kimura et al., Invest Ophthalmol Vis Sci 2008
:
The abundance of neither ZO-1 nor
occludin was
affected by
TNF-alpha
Cui et al., Braz J Med Biol Res 2010
:
Western blot results indicated that
TNF-alpha decreased the expression of phosphorylated occludin in detergent-insoluble fractions but did not
affect the expression of non phosphorylated
occludin protein
Fischer et al., Am J Physiol Gastrointest Liver Physiol 2013
:
In addition,
TNF-a induced a downregulation of claudin-1, claudin-2, claudin-4, and
occludin as well as activation of phosphatidylinositol 3-kinase signaling in T-84 but not Caco-2 cells, which was reversed by adalimumab
Hardyman et al., J Allergy Clin Immunol 2013
(Asthma) :
TNF-a lowered transepithelial electrical resistance and increased fluorescent dextran permeability,
caused loss of
occludin and claudins from tight junctions with redistribution of p120 catenin and E-cadherin from adherens junctions, and also increased endogenous TNF-a, IL-6, IL-1ß, IL-8, thymic stromal lymphoprotein, and pro-matrix metalloprotease 9 release