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PI3 — PRKAR1B

Text-mined interactions from Literome

Alexander et al., Invest Ophthalmol Vis Sci 2001 : Agents that modulate protein kinase A (PKA) or inhibit phosphatidylinositol 3-kinase (PI3K) had minimal effects on trabecular MMP or TIMP induction by TNFalpha, whereas several agents that modulate PKC activity were effective
Trümper et al., J Endocrinol 2002 (MAP Kinase Signaling System) : These interactions included : ( i ) a central role of tyrosine phosphorylation for stimulation of PKA/CREB, MAPK and PI3-kinase/PKB, ( ii ) inhibition of PKA/CREB by the MAPK pathway at the level of MAPK kinase-1 or downstream, ( iii ) activation of MAPK signaling by PI3-kinase and PKA at the level of extracellular-signal regulated kinase 1/2 or upstream, and ( iv ) activation of PKB by MAPK and PKA signaling at the level of PKB or upstream
Luconi et al., J Cell Sci 2004 : These results demonstrate that PI 3-kinase negatively regulates sperm motility by interfering with AKAP3-PKA binding, providing the first evidence of a molecular mechanism by which PKA can be targeted to sperm tails by interaction with tyrosine phosphorylated form of AKAP3
Carini et al., Gastroenterology 2004 (Reperfusion Injury) : In the cells treated with CGS21680, PI3K activation was prevented either by inhibiting adenylate cyclase and PKA with, respectively, 2,5-dideoxyadenosine and H89 or by blocking Galphai-protein and Src tyrosine kinase with, respectively, pertussis toxin and PP2
Park et al., Biochem Biophys Res Commun 2009 : HO-1 expression by PGE ( 2 ) was inhibited by LY294002, PI3K inhibitor and H89, PKA inhibitor
Agati et al., J Biol Chem 1998 : Thus, insulin inhibition of PKA induced PEPCK expression does not require MAPK activation but does require activation of PI3-kinase , although this signal is not transmitted through the PKB or PKC pathways