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ANGPT2 — ECM1

Text-mined interactions from Literome

Ha et al., Nephrology (Carlton) 2005 (Diabetic Nephropathies) : PKC, TGF-beta1, Ang II , and AGE also induce cellular ROS and signal through ROS leading to enhanced ECM synthesis
Takenaka et al., J Mol Cell Cardiol 2006 (Heart Failure...) : Local activation of Ang-II in hypertrophic LV triggers MMP mediated ECM degradation, namely LV remodeling, at least in part, through NADPH oxidase induced oxidative stress and the subsequent NFkappaB activation
de Cavanagh et al., Am J Physiol Heart Circ Physiol 2009 (Cardiovascular Diseases) : Also, by inducing integrin/focal adhesion changes, ANG II regulates ECM and cytoskeletal composition and organization and, accordingly, contributes to the pathogenesis of cardiovascular remodeling