Gene interactions and pathways from curated databases and text-mining

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Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kondrikov et al., Am J Physiol Lung Cell Mol Physiol 2006 : Decrease in eNOS association with beta-actin by silencing beta-actin expression using beta-actin siRNA causes inhibition of eNOS activity, NO production, and endothelial monolayer wound repair in PAEC
Ou et al., Arterioscler Thromb Vasc Biol 2005 : Our data demonstrate that beta-actin as a transcription factor stimulates eNOS expression ; and the transcriptional effect appears to be 27nt dependent
Ji et al., Proc Natl Acad Sci U S A 2007 : beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90
Kondrikov et al., J Biol Chem 2010 : We have previously reported that beta-actin is associated with eNOS oxygenase domain and that association of eNOS with beta-actin increases eNOS activity and nitric oxide ( NO ) production