◀ Back to CCND1

CCND1 — CDC42

Text-mined interactions from Literome

Bauerfeld et al., Am J Physiol Lung Cell Mol Physiol 2001 : Cdc42 , but not RhoA, regulates cyclin D1 expression in bovine tracheal myocytes ... Here, we examined the regulation of cyclin D1 expression by Cdc42 and RhoA ... Furthermore, dominant negative Cdc42 , but not RhoA, attenuated platelet derived growth factor mediated activation of the cyclin D1 promoter ... Cdc42 induced cyclin D1 promoter activation was independent of ERK as evidenced by insensitivity to PD-98059, an inhibitor of mitogen activated protein kinase/ERK kinase ( MEK )
Roovers et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : Inhibition of either MLCK or Rho kinase blocked sustained ERK signaling, but only Rho kinase inhibition allowed for the induction of cyclin D1 and activation of cdk4 via Rac/Cdc42
Roovers et al., Dev Cell 2003 : Instead, specific mutation of its nuclear localization and export sequences showed that LIM kinase acts in the nucleus to suppress Rac/Cdc42 dependent cyclin D1 expression