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AKT1 — PLK1

Text-mined interactions from Literome

Shtivelman et al., Mol Cancer Res 2003 : The checkpoint protein CHFR implicated in degradation of Plk1 is involved in the regulation of Plk1 by PKB ... Expression of a mutant form of CHFR that can not be phosphorylated by PKB results in reduction of levels of Plk1 and inhibition of mitotic entry under normal conditions and after DNA damage ... The deregulated activation of PKB that occurs frequently in tumors might inhibit CHFR activity after DNA damage and therefore promote Plk1 accumulation leading to the disruption of the DNA damage checkpoint
Leonard et al., Cell cycle (Georgetown, Tex.) 2013 : In primary keratinocytes, knockdown of PTEN increased whole-cell levels of ?-tubulin and PLK-1 in an Akt dependent manner and had little effect on recruitment of either protein to mitotic centrosomes ... Inhibition of Akt activation with MK2206 reduced the whole-cell and centrosome levels of PLK-1 and ?-tubulin and also prevented the recruitment of PTEN to mitotic centrosomes ... Inhibition of Akt activation with MK2206 reduced the whole-cell and centrosome levels of PLK-1 and ?-tubulin and also prevented the recruitment of PTEN to mitotic centrosomes
Kasahara et al., Nature communications 2013 : Inhibition of phosphatidylinositol 3-kinase (PI3K) and Akt significantly reduces the level of Plk1-Ser99 phosphorylation and delays metaphase to anaphase transition ... Plk1-Ser99 phosphorylation requires not only Akt activity but also protein ( s ) associated with Plk1 in a mitosis-specific manner