Villa et al., Mol Endocrinol 2004
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Unliganded TR does not bind to DNA and allows Sp1 to bind to DNA and stimulate APP basal expression ... Binding of ligand T ( 3 ), which increases affinity of TR by DNA, precludes binding of Sp1 to DNA and decreases the Sp1 dependent expression of APP Cieslik et al., J Biol Chem 1998
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These results suggest that lyso-PC up-regulates eNOS transcription by a PP2A dependent increase in Sp1 binding activity