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IL17A — IL2

Text-mined interactions from Literome

Liu et al., Mol Cells 2005 : Surprisingly, however, the pattern of regulation of IL-17 is different in mice than in humans, because `` costimulation '' of T cells through CD28 only mildly enhanced IL-17 expression, whereas levels of IL-2 were dramatically enhanced
Kryczek et al., J Immunol 2007 (Melanoma, Experimental...) : We now show that IL-2 reduces IL-17 ( + ) T cell differentiation in the tumor microenvironment accompanied with an enhanced Treg cell compartment in vitro and in vivo
Kryczek et al., J Immunol 2007 : Furthermore, although IL-2 reduces IL-17 ( + ) T cell differentiation, IL-1 completely disables this effect
Reddy et al., Cell Immunol 2007 : CNTO 1275 inhibited upregulation of CLA, IL-12R, IL-2Ralpha and CD40L expression and also inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A , tumor necrosis factor (TNF)-alpha, IL-2, and IL-10 secretion
Fan et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007 (Autoimmune Diseases) : IL-2 and IL-15 induced the production of IL-17 and IFN-gamma in a dose dependent manner by PBMCs. Similar results were confirmed by ELISPOT assay ... Further study suggested that IL-23, IL-2 and IL-15 directly induced the production of IL-17 and IFN-gamma by purified CD4 ( + ) T cells ... IL-23, IL-2 and IL-15 can directly induce CD4 ( + ) T cells to produce IL-17 and IFN-gamma
Lan et al., J Autoimmun 2008 : Finally, IL-2 not only plays a key role in the induction of effector T cells and regulatory T cells, it also inhibits IL-17 producing T cells
Guo et al., J Immunol 2009 (Chagas Disease) : Furthermore, and in contrast to the effects of IL-2 on Th17 development, IL-2 had no effect on IL-17 production by primed T cells
Cella et al., Proc Natl Acad Sci U S A 2010 : IL-2 reduced secretion of IL-22 and IL-17 , increasing production of IFN-gamma and leukemia inhibitory factor
Ndhlovu et al., J Clin Immunol 2010 (HIV Infections) : Previous studies on the effects of IL-2 on IL-17 secretion in non-HIV models have shown divergent results ... We hypothesized that IL-2 would mediate changes in IL-17 levels among recently HIV-1 infected adults receiving anti-retroviral therapy
Freches et al., Clinical and vaccine immunology : CVI 2011 (Tuberculosis) : Increased pulmonary tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine treated, Mycobacterium bovis BCG vaccinated mice
Yang et al., Nat Immunol 2011 : Whereas STAT3 induced IL-17 and the transcription factor ROR?t and inhibited the transcription factor Foxp3, IL-2 inhibited IL-17 independently of Foxp3 and ROR?t
Yamashita et al., Jpn J Infect Dis 2013 (Latent Tuberculosis) : However, we found a significant increase over healthy controls in ( i ) the IL-2 response to HBHA in recovery stage TB cases, ( ii ) the number of M. tuberculosis-specific polyfunctional CD4 ( + ) T cells in on-treatment and recovery stage cases, and ( iii ) the IL-17 response to HBHA and MDP-1 in on-treatment and recovery stage cases