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FUT1 — LEP

Text-mined interactions from Literome

Oben et al., Biochem Biophys Res Commun 2003 (Liver Cirrhosis) : We manipulated adrenergic activity in leptin-deficient ob/ob mice, leptin-sufficient, dopamine beta-hydroxylase deficient ( Dbh ( -/- ) ) mice, and HSC cultures to determine if leptin requires NE to activate HSC and induce hepatic fibrosis ... Supplemental leptin increases HSC , suggesting that leptin dependent, injury related factors permit expansion of HSC populations ... Thus, leptin permits injury related increases in adrenergic activity and requires NE to activate HSC and induce hepatic fibrogenesis
Choudhury et al., Metabolism 2006 : At these concentrations, leptin does not affect MMP-1 or TIMP-1 expression or collagenolytic activity of HSC
Lee et al., Histochem Cell Biol 2007 : Since the association of these two factors in HSC activation has not been demonstrated, we hypothesized that PPAR-gamma ligands would suppress leptin induced HSC activation and regulate leptin receptor expression
Tang et al., Endocrinology 2009 : This project is to evaluate the effect of curcumin on leptin induced HSC activation and to elucidate the underlying mechanisms ... In conclusion, our results demonstrate that curcumin abrogates the stimulatory effect of leptin on HSC activation in vitro by reducing the phosphorylation level of Ob-R, stimulating peroxisome proliferator activated receptor-gamma activity, and attenuating oxidative stress, leading to the suppression of Ob-R gene expression and interruption of leptin signaling
Wang et al., Gastroenterology 2009 (Disease Models, Animal...) : Leptin mediates HSC activation and liver fibrosis through indirect effects on KC ; these effects are partly mediated by TGF-beta1
Tang et al., Endocrinology 2010 : We recently reported that leptin stimulated HSC activation, which was eliminated by curcumin, a phytochemical from turmeric ... We hypothesized that one of the mechanisms by which leptin stimulated HSC activation was to stimulate the depletion of intracellular lipids, which could be abrogated by curcumin by inducing expression of genes relevant to lipid accumulation ... In summary, curcumin eliminated stimulatory effects of leptin on HSC activation and increased AMPK activity, leading to inducing expression of genes relevant to lipid accumulation and elevating the level of intracellular lipids ... These results provide novel insights into mechanisms of curcumin in inhibiting leptin induced HSC activation
Tang et al., Br J Pharmacol 2010 : We recently reported that leptin stimulated HSC activation, which was eliminated by curcumin, a phytochemical from turmeric ... We hypothesized that leptin stimulated HSC activation by elevating the level of intracellular glucose, which was eliminated by curcumin by inhibiting the membrane translocation of glucose transporter-4 (GLUT4) and inducing the conversion of glucose to glucose-6-phosphate ( G-6-P ) ... Our results provide novel insights into mechanisms of curcumin in inhibiting leptin induced HSC activation
Aleffi et al., Am J Physiol Gastrointest Liver Physiol 2011 (Neovascularization, Pathologic) : We investigated the pathways regulating hypoxia-inducible factor 1a (HIF-1a) and vascular endothelial growth factor ( VEGF ) in leptin stimulated myofibroblastic HSC ... Both leptin and PDGF increased the expression of HIF-1a and VEGF in HSC ... Leptin increased the generation of reactive oxygen species in HSC , which was reduced by NADP ( H ) oxidase inhibitors