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AKT3 — PLAT
Text-mined interactions from Literome
Lee et al., J Neurochem 2007
:
Consistent with neurotrophic effects,
tPA activated Raf-K/ERK, PKC and
PI3-K/Akt , 5-60 min after treatment
An et al., Blood 2008
(Brain Ischemia...) :
We found that, in the early phases of the ischemic insult, the interaction between
tPA and LRP
induces Akt phosphorylation ( pAkt ) in perivascular astrocytes and inhibits pAkt in neurons
Pineda et al., Glia 2012
(MAP Kinase Signaling System) :
We found that
tPA induces a catalytic independent rapid and sustained activation of extracellular signal regulated kinase ( ERK ) 1/2, Jun N-terminal kinase (JNK),
Akt , and p38 signaling pathways
Wang et al., Ann Neurol 2013
(Brain Ischemia...) :
Furthermore, rADAMTS13 downregulated
tPA induced phosphorylation of
Akt and activation of RhoA
Cho et al., Life Sci 2013
:
Glucose deprivation induced activation of
PI3K-Akt-GSK3ß , p38 and AMPK, and inhibition of these pathways using LY294002, SB203580 and compound C significantly
inhibited glucose deprivation induced
tPA down-regulation, demonstrating the essential role of these pathways in tPA regulation in glucose deprived astrocytes