◀ Back to GRB2
GRB2 — SOS2
Pathways - manually collected, often from reviews:
-
KEGG Dorso-ventral axis formation:
SOS1/SOS2
→
GRB2
(protein-protein, binding/association)
-
KEGG Focal adhesion:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Gap junction:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Jak-STAT signaling pathway:
SOS1/SOS2
→
GRB2
(protein-protein, binding/association)
-
KEGG Natural killer cell mediated cytotoxicity:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG T cell receptor signaling pathway:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG B cell receptor signaling pathway:
GRB2
→
SOS1/SOS2
(protein-protein, binding/association)
-
KEGG Fc epsilon RI signaling pathway:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Neurotrophin signaling pathway:
GRB2
→
SOS1/SOS2
(protein-protein, binding/association)
-
KEGG MAPK signaling pathway:
SOS1/SOS2
→
GRB2
(protein-protein, binding/association)
-
KEGG Insulin signaling pathway:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG GnRH signaling pathway:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Hepatitis C:
GRB2
→
SOS1/SOS2
(protein-protein, binding/association)
-
KEGG Pathways in cancer:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Renal cell carcinoma:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Endometrial cancer:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Glioma:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Glioma:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Prostate cancer:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Chronic myeloid leukemia:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Acute myeloid leukemia:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Non-small cell lung cancer:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG ErbB signaling pathway:
GRB2
→
SOS1/SOS2
(protein-protein, activation)
-
KEGG Chemokine signaling pathway:
GRB2
→
SOS1/SOS2
(protein-protein, binding/association)
-
NCI Pathway Database Regulation of Ras family activation:
None
→
GRB2/SOS2 complex (GRB2-SOS2)
(modification, collaborate)
Gureasko et al., Nature structural & molecular biology 2008, Yang et al., J Biol Chem 1995*, Nielsen et al., Mol Cell Biol 1997*
Evidence: assay
-
NCI Pathway Database Regulation of Ras family activation:
HRAS/GDP complex (HRAS)
→
GRB2/SOS2 complex (GRB2-SOS2)
(modification, collaborate)
Gureasko et al., Nature structural & molecular biology 2008, Yang et al., J Biol Chem 1995*, Nielsen et al., Mol Cell Biol 1997*
Evidence: assay
-
WikiPathways Chemokine signaling pathway:
GRB2
→
SOS1/SOS2
(unknown)
-
WikiPathways DNA Damage Response (only ATM dependent):
Complex of GRB2-SOS1-SOS2
→
HRAS/KRAS/NRAS
(activation)
-
WikiPathways DNA Damage Response (only ATM dependent):
SHC1
→
Complex of GRB2-SOS1-SOS2
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
SOS2
—
GRB2
(physical association, affinity chromatography technology)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Biogrid Interaction:
SOS2
—
GRB2
(direct interaction, two hybrid)
Yang et al., J Biol Chem 1995*
-
IRef Biogrid Interaction:
SOS2
—
GRB2
(physical association, affinity chromatography technology)
Bisson et al., Nat Biotechnol 2011
-
IRef Biogrid Interaction:
SOS2
—
GRB2
(direct interaction, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Biogrid Interaction:
SOS2
—
GRB2
(direct interaction, two hybrid)
Bandyopadhyay et al., Nat Methods 2010
-
IRef Biogrid Interaction:
SOS2
—
GRB2
(physical association, affinity chromatography technology)
Scholler et al., Eur J Immunol 2000*
-
IRef Hprd Interaction:
SOS2
—
GRB2
(in vivo)
Scholler et al., Eur J Immunol 2000*, Schulze et al., J Biol Chem 2004, Yang et al., J Biol Chem 1995*
-
IRef Intact Interaction:
SOS2
—
GRB2
(physical association, pull down)
Schulze et al., J Biol Chem 2004
-
IRef Intact Interaction:
SOS2
—
GRB2
(physical association, coimmunoprecipitation)
Schulze et al., J Biol Chem 2004
-
IRef Intact Interaction:
SOS2
—
GRB2
(physical association, peptide array)
Wu et al., Proteomics 2007
-
IRef Intact Interaction:
SOS2
—
GRB2
(physical association, two hybrid pooling approach)
Bandyopadhyay et al., Nat Methods 2010
-
IRef Intact Interaction:
SOS2
—
GRB2
(physical association, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Intact Interaction:
SOS2
—
GRB2
(physical association, two hybrid)
Yang et al., J Biol Chem 1995*
-
IRef Intact Interaction:
SOS2
—
GRB2
(physical association, anti tag coimmunoprecipitation)
Yang et al., J Biol Chem 1995*
-
IRef Intact Interaction:
Complex of 28 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
-
IRef Ophid Interaction:
SOS2
—
GRB2
(aggregation, confirmational text mining)
Yang et al., J Biol Chem 1995*
-
IRef Ophid Interaction:
SOS2
—
GRB2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Chesnel et al., Biol Cell 2003
:
We also demonstrate that, like p60 ( Xl ) ( Shc ), Grb2 and the guanine nucleotide exchange factor
Sos are expressed in oocytes throughout vitellogenesis and in early embryos and that overexpression of a dominant negative form of
Grb2 specifically
inhibits insulin induced resumption of meiosis
Goudreau et al., Nat Struct Biol 1994
:
GRB2 couples receptor tyrosine kinase
activation to Ras signalling by interacting, through its SH3 domains, to the carboxy-terminal proline-rich regions of the guanine nucleotide exchange factor
Sos
Buday et al., Cell 1993
(Carcinoma, Squamous Cell) :
In vitro reconstitution shows that
Grb2 is
required for the binding of activated EGF receptor to
Sos
Wong et al., J Biol Chem 1996
:
Additional experiments indicated that neither the binding of the nucleotide exchange factor
Sos to GRB2 nor tyrosine phosphorylation of PTP1D was
required for EGF stimulated coupling of PTP1D to
GRB2
Zhang et al., Anal Biochem 1996
:
Using epidermal growth factor (EGF) receptor, Grb2 and Sos proteins as an example, we demonstrated the use of the three-hybrid system to detect formation of a three-component complex, i.e., the
Grb2 mediated interactions between EGF receptor and
Sos
Jefferson et al., Oncogene 1998
:
Binding of
Grb2 to SOS did not
prevent the inhibition of
SOS by PtdIns4,5P2 suggesting that there must be another mechanism for regulating this inhibition