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Liu et al., Carcinogenesis 1999 (Papilloma...) : In this report we demonstrate that the antioxidant N-acetylcysteine (NAC) , a well-known chemopreventive agent, induces p16(INK4a) and p21 ( WAF1/CIP1 ) gene expression and prolongs cell-cycle transition through G ( 1 ) phase
Wu et al., J Pharmacol Exp Ther 2005 : Expression of tumor suppressor p53 and the cell cycle regulatory protein p21 was stimulated within 5 to 10 min by cisplatin in p53 positive LX-1 small cell lung carcinoma cells, and this effect was blocked by NAC
Huang et al., American journal of physiology. Renal physiology 2007 (Hyperglycemia...) : Moreover, NAC and taurine increased cyclin D1/cdk4 activation and suppressed p21 ( Waf1/Cip1 ) and p27 ( Kip1 ) expression in HG-treated cells
Huang et al., Toxicological sciences : an official journal of the Society of Toxicology 2009 (Hypertrophy) : The abilities of NO and antioxidants to inhibit AGE/RAGE induced hypertrophic growth were verified by the observation that SNAP, SNP, NAC , and taurine inhibited fibronectin, p21 ( Waf1/Cip1 ), and RAGE expression