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AKT1 — IFNG

Text-mined interactions from Literome

Nguyen et al., J Biol Chem 2001 : IFN gamma activates PI3K as well as Akt in a variety of cell lines
Navarro et al., J Leukoc Biol 2003 : In this study, we demonstrate that IFN-beta or IFN-gamma induces the phosphorylation of the serine/threonine kinase Akt in primary human peripheral blood monocytes
Sakamoto et al., J Leukoc Biol 2005 : Stimulation of neutrophils with IFN-alpha or IFN-gamma resulted in tyrosine phosphorylation of STAT1 and STAT3 but not phosphorylation of STAT5, Akt , extracellular signal regulated kinase, and p38 mitogen activated protein kinase
Venkatesan et al., Cell Signal 2006 : IFN-gamma increased Akt kinase activity in a PI 3 kinase dependent manner ... IFN-gamma had no effect on this complex formation, but did increase PKCepsilon associated Akt kinase activity
Boulday et al., J Immunol 2006 : Moreover, we show that VEGF and IFN-gamma regulate the activation of the IP-10 promoter, and that the kinases PI3K, phosphoinositide dependent kinase 1, and Akt act as intermediary signaling molecules for cytokine-inducible IP-10 transcriptional activation in endothelial cells
Rosner et al., Am J Pathol 2006 (Atherosclerosis) : Interferon-gamma induces Fas trafficking and sensitization to apoptosis in vascular smooth muscle cells via a PI3K- and Akt dependent mechanism ... IFN-gamma also stimulated Akt activity, and both Fas trafficking and Stat1 activation were inhibited by blocking PI3K, Akt, or Jak-2
Hwang et al., Int J Hematol 2006 : IFN-gamma did not enhance SDF-1 induced activation of PI3K/Akt or up-regulate the expression of CXCR4 or its function in bone marrow CD34+ cells
Harvey et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis) : These studies provide novel insights into the role of PI3K/AKT and CK2 in IFN-gamma signaling relevant to changes in macrophage gene expression during atherosclerosis
Boisvert et al., Mol Immunol 2007 : Inhibition studies indicated that activation of ERK and JNK MAPKs and PI3K/AKT are necessary for both TCR- and TCR+alpha2 beta1 integrin dependent IFN-gamma production and that Coll I increases TCR dependent activation of ERK and JNK MAPKs, and AKT
Liu et al., Ann Hematol 2007 (Anemia, Aplastic) : IFN-gamma attenuated Akt phosphorylated by G-CSF in a dose- and time dependent manner
Li et al., Crit Care 2008 (Acute Lung Injury...) : High-tidal-volume ventilation induced type I and type III procollagen mRNA expression, microvascular permeability, hydroxyproline content, Masson 's trichrome staining, S100A4/fibroblast specific protein-1 staining, activation of Akt and extracellular signal regulated kinase ( ERK ) 1/2, and production of macrophage inflammatory protein-2 and 10 kDa IFNgamma-inducible protein in a dose dependent manner
Peairs et al., Clin Exp Immunol 2009 (Lupus Nephritis) : Mechanistically, AICAR inhibited the LPS/IFN-gamma stimulated PI3K/Akt signalling inflammatory cascade but did not affect LPS/IFN-gamma mediated inhibitory kappa B phosphorylation or nuclear factor (NF)-kappaB ( p65 ) nuclear translocation ... Taken together, these observations suggest that AICAR inhibits LPS/IFN-gamma induced Akt phosphorylation through AMPK activation and may serve as a potential therapeutic target in inflammatory diseases
Grzelkowska-Kowalczyk et al., Cell Mol Biol Lett 2010 : The aim of this study was to compare the effects of TNF-alpha, IL-1beta and IFN-gamma on the activation of protein kinase B (PKB) , p70 ( S6k ), mitogen activated protein kinase ( MAPK ) and p90 ( rsk ), and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes
Grzelkowska-Kowalczyk et al., Cell Biol Int 2010 : The purpose of the present study was to examine the potential effect of IFN-gamma ( interferon-gamma ) on the cellular content and phosphorylation of PKB ( protein kinase B ), p70S6k ( p70 S6 kinase ) and MAPK ( mitogen activated protein kinase ), and on the ability of insulin to stimulate the glucose uptake and protein synthesis in mouse C2C12 myotubes
Okubo et al., Mol Nutr Food Res 2010 : Phenethyl isothiocyanate suppresses nitric oxide production via inhibition of phosphoinositide 3-kinase/Akt induced IFN-gamma secretion in LPS activated peritoneal macrophages