◀ Back to PIK3R3

IRS1 — PIK3R3

Pathways - manually collected, often from reviews:

• KEGG Neurotrophin signaling pathway: IRS1/IRS2/IRS4 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Insulin signaling pathway: IRS1/IRS2/IRS4 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Type II diabetes mellitus: IRS1 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Type II diabetes mellitus: IRS1/IRS2/IRS4 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Aldosterone-regulated sodium reabsorption: IRS1/IRS2/IRS4 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• WikiPathways Insulin Signaling: PIK3CD/PIK3C3/PIK3R3/PIK3R1/PIK3C2G/PIK3R2/PIK3CG/PIK3CB/PIK3R4/PIK3C2A/PIK3CA → Complex of IRS1-PIK3CA (activation)
• WikiPathways DNA Damage Response (only ATM dependent): IRS1 → PIK3CA/PIK3CB/PIK3CG/PIK3CD/PIK3R1/PIK3R2/PIK3R3/PIK3R4/PIK3R5/PIK3C2A/PIK3C2B/PIK3C2G/PIK3C3 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IRS1 — PIK3R3 (physical association, affinity chromatography technology) Xia et al., Biochem J 1999*
• IRef Biogrid Interaction: IRS1 — PIK3R3 (physical association, affinity chromatography technology) Mothe et al., Mol Endocrinol 1997*
• IRef Hprd Interaction: IRS1 — PIK3R3 (in vitro) Xia et al., Biochem J 1999*, Pons et al., Mol Cell Biol 1995*, Mothe et al., Mol Endocrinol 1997*
• IRef Hprd Interaction: IRS1 — PIK3R3 (in vivo) Xia et al., Biochem J 1999*, Pons et al., Mol Cell Biol 1995*, Mothe et al., Mol Endocrinol 1997*
• IRef Ophid Interaction: IRS1 — PIK3R3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005