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EPHB2 — HMOX1
Text-mined interactions from Literome
Chen et al., Cell Mol Biol Incl Cyto Enzymol 2000
:
ERK and p38 inhibitors also
suppressed induction of
HO-1 by SNAP and GSNO
Zhang et al., Am J Physiol Lung Cell Mol Physiol 2002
(Lung Diseases...) :
We also demonstrate that
HO-1 gene transcription after A-R
involves ERK , JNK, and p38 MAPK pathways
Liu et al., Life Sci 2004
(MAP Kinase Signaling System) :
Although 15d-PGJ ( 2 ) significantly activated the MAPKs of JNK and ERK, the activation of JNK and
ERK did not
contribute to the induction of
HO-1 as determined using transfection of dominant negative plasmids and MAPKs inhibitors
Chen et al., J Cell Biochem 2004
(Carcinoma, Papillary...) :
The induced levels of
HO-1 and p21 were significantly
reduced by p38 mitogen activated protein kinase ( p38 MAPK ) and
extracellular regulated kinase (ERK) inhibitors
Gong et al., Arch Biochem Biophys 2004
(Hepatoblastoma) :
Both
ERK and p38 pathways
play an important role in DAS induced Nrf2 nuclear translocation and
ho-1 gene activation
Anwar et al., Free Radic Biol Med 2005
(Arteriosclerosis...) :
These findings demonstrate for the first time that activation of PKC, p38 ( MAPK ), JNK,
ERK1/2 , and Nrf2 by oxidized LDL in human SMC
leads to
HO-1 induction, constituting an adaptive response against oxidative injury that can be ameliorated by vitamin C
Iles et al., Free Radic Biol Med 2005
:
Whereas inhibiting the ERK pathway with the MEK inhibitor PD98059 significantly decreased HNE mediated
ERK phosphorylation, c-Fos protein induction, AP-1 binding, and
HO-1 protein
induction , inhibition of the ERK pathway had no effect on HNE induced HO-1 mRNA ... This suggests that
ERK is
involved in the increase in
HO-1 through regulation of translation rather than transcription
Watanabe et al., Am J Pathol 2006
:
Inhibition of
ERK activation with MEK inhibitors ( PD98059 or U0126 )
diminished induction of the antioxidant enzyme
heme oxygenase-1
Oh et al., Free Radic Biol Med 2006
:
Both H ( 2 ) S solution prepared by bubbling pure H ( 2 ) S gas and NaSH, a H(2)S donor, dose dependently
induced HO-1 expression through the activation of the extracellular signal regulated kinase (
ERK )
Xu et al., Mol Cancer Ther 2006
(Prostatic Neoplasms) :
Activation of
ERK and JNK signaling also
resulted in the elevation of ARE activity and
HO-1 expression
Woo et al., J Biol Chem 2006
(Inflammation) :
We found that overexpression of
HO-1 and [ Ru ( CO ) ( 3 ) Cl(2) ] ( 2 ), a carbon monoxide ( CO ) -releasing compound,
increased not only
ERK5 kinase activity, but also its transcriptional activity measured by luciferase assay with the transfection of the Gal4-ERK5 reporter gene
Cooper et al., Toxicol Appl Pharmacol 2007
:
These findings suggest that the
ERK/MAPK activation is
necessary but not sufficient for optimal arsenite stimulated
HO-1 induction
Kim et al., Ann N Y Acad Sci 2006
:
To determine whether the induction of
HO-1 is
responsible for
ERK1/2 activation, the HO-1 inhibitor, zinc protoporphyrin ( ZnPP ) was used
Sun et al., Life Sci 2008
(MAP Kinase Signaling System) :
YS 49 induced
HO-1 protein production in a dose-and time dependent manner in VSMCs. Treatment with YS 49 significantly and dose-dependently
inhibited Ang II-induced VSMC proliferation, ROS production, and phosphorylation of JNK, but not P38 MAP kinase or
ERK1/2
Hsu et al., J Cell Physiol 2008
:
Herein, we show that Curcumin dose dependently
induced HO-1 expression and
HO-1 activity through the activation of PKCalpha,
PKCdelta/ERK1/2 , p38alpha, and PI3-kinase
Hwang et al., Toxicol Appl Pharmacol 2008
:
Metallothionein-III protects against 6-hydroxydopamine induced oxidative stress by increasing expression of
heme oxygenase-1 in a PI3K and
ERK/Nrf2 dependent manner
Rémy et al., J Immunol 2009
:
HO-1 and CO inhibited LPS induced activation of the IFN regulatory factor 3 pathway and their effects were
independent of p38,
ERK , and JNK MAPK
Takagi et al., J Pharmacol Exp Ther 2009
:
Phosphorylation of
ERK and Nrf2, activation and nuclear translocation of Nrf2, and oxidation of Keap1 are all
involved in the lansoprazole induced
HO-1 up-regulation
Goven et al., FEBS Lett 2009
(Emphysema...) :
These results suggest that
ERK ( 1/2 ) and JNK are
involved in CS-induced biphasic
HO-1 expression by a specific regulation of Nrf2/Keap1-Bach1
Park et al., Biochimie 2010
(Colonic Neoplasms) :
The pharmacological inhibition of
ERK and p38 MAPK
inhibited rottlerin induced
HO-1 up-regulation
Chen et al., J Agric Food Chem 2010
:
Besides,
ERK1/2 inhibitor significantly
inhibited hesperidin mediated
HO-1 upregulation and Nrf2 nuclear translocation
Li et al., Acta Pharmacol Sin 2010
:
By inhibiting
HO-1 activity with ZnPP IX, the inhibitive effect of neferine on
ERK1/2 phosphorylation was significantly
attenuated
Lu et al., Biol Psychiatry 2010
(Inflammation) :
In addition, DHA caused AKT and ERK activation in a time dependent manner, and the DHA induced
HO-1 upregulation could be
attenuated by PI-3 kinase/AKT and
MEK/ERK inhibitors
Chen et al., Food Chem Toxicol 2010
:
Western blot showed that hesperidin facilitated
ERK/MAPK phosphorylation which appeared to be responsible for nuclear translocation of Nrf2, thereby
inducing cytoprotective
heme oxygenase-1 (HO-1) expression
Yang et al., Free Radic Biol Med 2011
:
These results suggest the
involvement of
ERK2 and Nrf2 in the induction of
HO-1 and GCLC by butein
Huang et al., Arch Toxicol 2013
:
Both
ERK2 and Nrf2 siRNAs
attenuated chrysin induced
HO-1 , GCLC, and GCLM protein expression
Chen et al., J Huazhong Univ Sci Technolog Med Sci 2012
:
Moreover, ß-PGG induced Nrf2 nuclear translocation, which was found to be upstream of ß-PGG induced HO-1 expression, and the
activation of
ERK and Akt, a pathway that is involved in ß-PGG induced Nrf2 nuclear translocation,
HO-1 expression and neuroprotection
Lin et al., PloS one 2012
(Neurodegenerative Diseases) :
Moreover, desipramine
induces HO-1 expression through activation of
ERK and JNK signaling pathways
Chien et al., Free Radic Biol Med 2013
(Genetic Predisposition to Disease...) :
Akt and
ERK are
involved in
HO-1 induction after oxidative stress
Gu et al., International journal of medical sciences 2013
(MAP Kinase Signaling System...) :
Additionally, the potential
roles of
ERK , p 38 MAPK and JNK in the regulation of propofol induced endogenous
HO-1 expression in SH-SY5Y cells were estimated by Western blotting assays