Gene interactions and pathways from curated databases and text-mining

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EPHB2 — MUC5AC

Text-mined interactions from Literome

SÅ‚omiany et al., J Physiol Pharmacol 2005 : The gastric mucin secretory responses to isoproterenol, furthermore, were inhibited by PP2, a selective inhibitor of tyrosine kinase Src responsible for ligand independent EGFR autophosphorylation, but not by ERK inhibitor, PD98059
Ha et al., J Immunol 2007 : A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae
Huang et al., Biochem Biophys Res Commun 2007 : Moreover, activation of both p38 and ERK is required for synergistic induction of MUC5AC by NTHi and EGF
Tadaki et al., J Immunol 2009 (MAP Kinase Signaling System) : This synergistic effect on MUC5AC production may be due to enhanced activation of ERK through inhibition of MKP3 by poly ( I:C )
Lim et al., American journal of translational research 2009 : In the present study, we showed that positive regulation of MUC5AC mucin expression by ERK1/2 is dependent on Ras-Raf-1 signaling pathway, whereas the negative regulation of MUC5AC expression by JNK1/2 is dependent on MEKK3 ... Ras-Raf1-ERK1/2 dependent AP-1 activation positively regulates MUC5AC mucin induction by S. pneumoniae, whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it
Li et al., Mol Biol Rep 2012 (MAP Kinase Signaling System) : p-ERK1/2 increased significantly in response to compressive stress and PD-98059 could attenuated stress induced MUC5AC expression
Morinaga et al., Can J Microbiol 2012 (MAP Kinase Signaling System) : Inhibitors of ERK and JNK, but not p38, dose-dependently inhibited the induction of MUC5AC by live L. pneumophila
Lee et al., J Biol Chem 2012 (MAP Kinase Signaling System...) : We previously reported that S. pneumoniae up-regulates MUC5AC expression in a MAPK ERK dependent manner ... We also found that MAPK phosphatase-1 (MKP-1) negatively regulates S. pneumoniae induced ERK dependent MUC5AC up-regulation